- Dr. Narasimham Parinandi
- Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
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Special Issue Introduction
Theme/Focus: Oxidants such as superoxide, hydroxyl radicals, hydrogen peroxide, and nitric oxide, along with transition metals, play crucial roles in the onset and progression of lung vascular diseases and health through oxidative stress and redox alterations. There are different enzymatic and non-enzymatic pathways through which oxidants are generated in the lung vasculature, which cause oxidative stress and antioxidant dysregulation/imbalance. In addition, external oxidants through the inhalation of environmental toxicants, smoking, and other respirable toxicants cause oxidative stress in the lung vasculature. Antioxidants (both enzymatic and non-enzymatic and nutritionally supplemented) play important roles in counteracting oxidative stress and protecting the tissue damage in the lung vasculature. Hence, oxidant-induced oxidative stress and antioxidant imbalance/dysregulation are emerging as important factors in pulmonary vascular diseases. It is high time to address the role of oxidative stress and antioxidant protection in pulmonary vascular diseases towards understanding the oxidant mechanism of those diseases for disease management and effective therapy.
The authors can contribute Original Research, Reviews, Case Studies, Hypothesis Papers, Clinical Studies, Research Models, Drug Discovery, and Methods in the area of “Oxidants and Antioxidants in Pulmonary Vascular Diseases”. There is no length restriction for any of these articles.
Oxidants, antioxidants, oxidative stress, pulmonary vascular diseases
Submission Deadline30 Aug 2022