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Topic: Macrophage Phenotypic Diversity and Its Role in a Dynamic Atherosclerotic Plaque Microenvironment: A potential Therapeutic Strategy Targeting Atherosclerosis

A special issue of Vessel Plus

ISSN 2574-1209 (Online)

Submission deadline: 15 Feb 2021

Guest Editor(s)

  • Dr. Rupinder Kaur Kanwar
    School of Medicine, Institute for Innovation in Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Australia.

    Website | E-mail

Special Issue Introduction

Atherosclerosis is a multifactorial chronic inflammatory disease of medium-to large-sized arteries, which stems with the lesion formation at the arterial wall. Currently affecting millions of people globally, atherosclerosis is the underlying cause of the majority of cardiovascular diseases. Macrophages are key players in the pathogenesis of atherosclerosis, and their presence in the developing lesions and plaques has been acknowledged as a defining hallmark of the disease. Considering the key role macrophages play in atherosclerotic inflammation, from lesion initiation to plaque rupture, the recent progress in the 21st century driven by cutting-edge single-cell technologies has advanced the comprehensive mapping of the different cell types and their phenotypes present in atherosclerotic plaques. This special issue focuses on understanding the dynamic atherosclerotic plaque microenvironment in terms of phenotypic diversity of macrophages and their roles during lesion development to plaque stability, rupture and regression, and the potential of macrophage phenotype modulation as a therapeutic strategy to prevent cardiovascular complications.


Atherosclerosis, inflammation, macrophage phenotypes, atherosclerotic plaque microenvironment, plaque regression, Single cell technologies, TERM2, cardiovascular diseases, macrophage, lipids

Submission Deadline

15 Feb 2021

Submission Information

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to http://vpjournal.net/pages/view/author_instructions
For Online Submission, please login at https://oaemesas.com/VP/?IssueId=515
Submission Deadline: 15 Feb 2021
Contacts: Alisa Wang, Assistant Editor, Alisa@vpjournal.net

Published Articles

This special issue is now open for submission.
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