- Dr. Rupinder Kaur Kanwar
- School of Medicine, Institute for Innovation in Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Australia.
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Special Issue Introduction
Atherosclerosis is a multifactorial chronic inflammatory disease of medium-to large-sized arteries, which stems with the lesion formation at the arterial wall. Currently affecting millions of people globally, atherosclerosis is the underlying cause of the majority of cardiovascular diseases. Macrophages are key players in the pathogenesis of atherosclerosis, and their presence in the developing lesions and plaques has been acknowledged as a defining hallmark of the disease. Considering the key role macrophages play in atherosclerotic inflammation, from lesion initiation to plaque rupture, the recent progress in the 21st century driven by cutting-edge single-cell technologies has advanced the comprehensive mapping of the different cell types and their phenotypes present in atherosclerotic plaques. This special issue focuses on understanding the dynamic atherosclerotic plaque microenvironment in terms of phenotypic diversity of macrophages and their roles during lesion development to plaque stability, rupture and regression, and the potential of macrophage phenotype modulation as a therapeutic strategy to prevent cardiovascular complications.
KeywordsAtherosclerosis, inflammation, macrophage phenotypes, atherosclerotic plaque microenvironment, plaque regression, Single cell technologies, TERM2, cardiovascular diseases, macrophage, lipids
Submission Deadline15 Feb 2021