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Topic: Emerging Trends on the Role of PDGFs and PDGFRs in Health and Disease

A special issue of Vessel Plus

ISSN 2574-1209 (Online)

Submission deadline: 30 Apr 2020

Guest Editor(s)

  • Prof. Shilpa Buch, Ph.D.
    Director- Nebraska Center for Substance Abuse Research
    Community Pride of Nebraska Professorship of Neuroscience
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center
    Omaha, NE 68198-5880, USA

    Website | E-mail

  • Dr. Palsamy Periyasmy, Ph.D.
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center
    Omaha, NE 68198-5880, USA

    Website | E-mail

  • Dr. Susmita Sil, Ph.D.
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center
    Omaha, NE 68198-5880, USA

    Website | E-mail

Special Issue Introduction

Platelet-derived growth factors (PDGFs) belong to a family of mesenchymal cysteine-knot-type mitogens. They are abundantly expressed in several tissues and are known to play vital roles in the formation of blood vessels, proliferation of mesenchymal cells and mesenchymal stem cells, directed migration of mesenchymal cells, wound healing and fibrosis. These biological functions are elicited through binding of these growth factors with their cognate receptors, namely PDGFR-α, and PDGFR-β. Members of the PDGF family play critical roles in both health and disease. It is well-recognized that autocrine PDGF signaling underlies the development of gliomas, sarcomas, and leukemias whereas paracrine PDGF signaling is involved in epithelial cancers, angiogenesis, atherosclerosis, restenosis, pulmonary hypertension, retinal diseases, pulmonary fibrosis, liver cirrhosis, scleroderma, glomerulosclerosis, and cardiac fibrosis, HIV neuropathogenesis and drug abuse. Therapy using PDGF antagonists as well as PDGF receptor-inhibiting substances, has been extensively tested in pre-clinical models as well as in human clinical trials. Despite substantial advances in our understanding of the biology of the members of the PDGF family, its paradoxical roles in normal cellular homeostasis and pathologies necessitate the need to examine their roles in disease and health. The goal of this special issue is to present emerging trends in the roles that PDGF and its receptors play in inflammatory disease processes underlying cardiovascular, cancer, stroke and neurodegenerative processes associated with aging, viral infection and substance abuse with the ultimate aim to pave the way for future therapeutic breakthroughs.

Keywords

PDGF, PDGFR, cancers, angiogenesis, atherosclerosis, pulmonary hypertension, retinal diseases, pulmonary fibrosis, liver cirrhosis, glomerulosclerosis, cardiac fibrosis, HIV neuropathogenesis, drug abuse

Submission Deadline

30 Apr 2020

Submission Information

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to http://vpjournal.net/pages/view/author_instructions
For Online Submission, please login at http://www.oaemesas.com/vp
Submission Deadline: 30 Apr 2020
Contacts: Mavis Wei, Assistant Editor, editor_12@oaepublish.com

Published Articles

This special issue is now open for submission.