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Topic:Recent insights into atherosclerosis: from causes to treatments

A special issue of Vessel Plus

ISSN 2574-1209 (Online)

Submission deadline: 30 Nov 2019

Guest Editor(s)

  • Dr. Shuang Chen
    Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, United States

    Website | E-mail

Special Issue Introduction

Atherosclerosis is a lipid-driven, chronic inflammatory disease of the vessel wall in which both innate and adaptive immune responses play a role. Atherosclerotic cardiovascular disease is the leading cause of morbidity and mortality globally. Organ systems, including heart, brain and kidneys, as well as extremities, can be damaged, leading to atherosclerosis-driven clinical outcomes. Infiltration and accumulation of plasma lipoproteins and leukocyte subsets is a driving force of atherosclerotic lesion growth. Treatment of atherosclerosis often begins with robust cholesterol-lowering treatments, yet many patients continue to experience cardiovascular events. Targeting inflammation by inhibiting pro- inflammatory cytokines has emerged as a novel promising mode of therapy to improve and complement the current lipid-lowering approaches. The goals of this issue are to: 1. discuss and question the current dogmas about atherosclerotic disease progression, learn about new molecules and new cellular pathways that mechanistically play a role in atherosclerosis development. 2. discuss how to utilize new high dimensional methods to study cellular and molecular components of the atherosclerotic plaque. 3. Explore cutting-edge technologies to discover new therapeutic targets and approaches for drug development.

Keywords

Atherosclerosis, inflammation, cholesterol , plaque, innate immune response, adaptive immune response, treatment

Submission Deadline

30 Nov 2019

Submission Information

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to http://vpjournal.net/pages/view/author_instructions
For Online Submission, please login at http://www.oaemesas.com/vp
Submission Deadline: 30 Nov 2019
Contacts: Ellie Liang, Managing Editor, editorialoffice@vpjournal.net

Published Articles

This special issue is now open for submission.