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Topic: Cerebral Cavernous Malformations: Possible Signaling Pathways and Potential Therapeutic Strategies

A special issue of Vessel Plus

ISSN 2574-1209 (Online)

Submission deadline: 31 Mar 2023

Guest Editor(s)

  • Dr. Robert Shenkar

    Department of Neurosurgery, University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.

    Website | E-mail

  • Dr. Jun Zhang
    Jun Zhang, Graduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA.

    Website | E-mail

Special Issue Introduction

Cerebral cavernous malformations (CCMs) are ectatic capillary-venous malformations that develop in approximately 0.5% of the population. These malformations, which can vary in size from 2 millimeters to several centimeters in diameter, may be hereditary but most often occur on their own as sporadic cases.  As opposed to other kinds of hemangiomas, CCM vessels, which have the appearance of a small mulberry, develop and create problems in the brain or spinal cord. Patients with CCMs may develop headaches, focal neurologic deficits, seizures, and hemorrhages. Up to date, neurosurgical resection is the only therapeutic option. Exploring new possible signaling pathways involved in pathogenesis might provide new strategic options for future CCM therapy and management. In this special issue, we aim to report the latest advances of CCMs, specifically in CCM-related signaling pathways and their correspondent therapeutic strategies.


Cerebral cavernous malformations, signaling, biomarkers, inflammation, therapeutics

Submission Deadline

31 Mar 2023

Submission Information

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to http://vpjournal.net/pages/view/author_instructions
For Online Submission, please login at https://oaemesas.com/login?JournalId=vp&SpecialIssueId=vp220326
Submission Deadline: 31 Mar 2023
Contacts: Alisa Wang, Assistant Editor, ALisa@vpjournal.net

Published Articles

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