fig1

Figure 1. Pathophysiological mechanisms of coronary microvascular disorders in relation to clinical manifestations and therapeutic targets. Pathophysiologic mechanisms in clear boxes. Clinical Manifestations (COVADIS Diagnostic Criteria) in blue shaded boxes. Therapeutic Strategies in blue free text. CFR: Coronary flow reserve; iMR: index of Microvascular resistance; hMR: hyperaemic microvascular resistance.