fig1

Figure 1. Vascular lesion formation after clonal expansion of mutated endothelial cells. Model of cerebral cavernous malformation (CCM) development in which a second hit promotes a postzygotic CCM mutation that leads to a clonal expansion and the recruitment of wild type endothelial cells into growing vascular lesions. This figure was created using Servier Medical Art templates, which are licensed under a Creative Commons Attribution 3.0 Unported License; https://smart.servier.com.