fig1

Figure 1. Schematic representation of KRIT1 gene and KRIT1 protein: (A) KRIT1 gene structure including 19 coding exons (rectangles) and introns (horizontal lines) (reference sequence: NM_004912.3); and (B) KRIT1 protein structure, including NUDIX domain, NPxY/F motifs, ankyrin repeat domains (ANK), and FERM domain (band 4.1 ezrin radixin moesin domain), composed of three subdomains. The position of the amino acid at the beginning and at the end is indicated for each domain.