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From:  Reversibility of adverse cardiac remodeling in type 2 diabetes mellitus patients: focus on sodium-glucose cotransporter-2 inhibitors
Reversibility of adverse cardiac remodeling in type 2 diabetes mellitus patients: focus on sodium-glucose cotransporter-2 inhibitors

Figure 1. Underlying pathogenetic mechanisms of tissue protective effects of SGLT2 inhibitors↑. Akt: Serine/threonine-specific protein kinase; HF: heart failure; CaMK: Ca2+/calmodulin-dependent protein kinase; mTOR: mammalian target of rapamycin; SGLT2: sodium-glucose cotransporter 2; PI3K: phosphatidylinositol 3-kinase; ↑: increase; ↓: decrease.

Vessel Plus
ISSN 2574-1209 (Online)
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