fig7

Figure 7. Body weight gain and adiposity of WT and AOC3KO male mice fed a standard diet (SD) or a high-fat diet (HFD). (A) WT (black squares) and AOC3KO (open squares) male mice were weighed weekly when fed ad libitum with a standard diet. (B) Body weight evolution for WT (black triangles) and AOC3KO (open triangles) male mice challenged with high-fat feeding for 20 weeks. Mean ± SEM from 11 mice per group in (A, C) and from 8 WT HFD and 12 AOC3KO HFD mice in (B, D). Significant influence of genotype on body weight at: *P < 0.05; **P < 0.01. (C, D) At the age of 28 weeks, intra-abdominal (INWAT), subcutaneous (SCWAT) and brown adipose tissues (BAT) were dissected and weighed. Differences between WT (black columns) and AOC3KO mice (white columns) significant at: *P < 0.05; **P < 0.01; ***P < 0.001.