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Figure 2. PCSK9-dependent effects on receptors expressed in cells in atherosclerotic plaques and the heart. PCSK9’s interactions with or effects on the LDL receptor, CD36, LRP-1, and LOX-1 in endothelial cells, vascular smooth muscle cells, monocytes/macrophages, platelets, and cardiomyocytes are summarized with effects that may alter downstream cell signalling mediating cell activation, cell migration, inflammation, and lipid uptake. References are provided in the text. Figure created with BioRender.com. LDL: low-density lipoprotein