fig3
From: Inhibition of cyclooxygenase activity by diclofenac attenuates varicose remodeling of mouse veins
Figure 3. Impact of elevated pressure levels on markers of cell activity. Isolated branches of the mesenteric vein of male NMRI mice were exposed to 4- or 16-mmHg, respectively in the presence or absence of diclofenac. Protein extracts generated from these blood vessels were analyzed by capillary electrophoresis as described above. The level of phosphorylated ERK1/2 and the abundance of MMP-2 (pro-enzyme: 72 kDa was below detection limit, active form: ~ 62 kDa) were determined; A: *P < 0.05 vs. 4 mmHg, #P < 0.05 vs. 16 mmHg, n = 4-5 as indicated; B: **P < 0.01 vs. 4 mmHg, ##P < 0.01 vs. 16 mmHg, n = 3-4 as indicated.
