fig2

Figure 2. The role of SNRK in maintaining tissue homeostasis. Phosphorylation or signaling of SNRK to maintain homeostasis in three systems - cardiac system, adipose system, and inflammatory system is shown. The arrow indicates whether the phosphorylation is activating (black) or inhibiting (red) for the function of the target protein. The proteins under each system have been implicated to communicate with SNRK in that system. SNRK: sucrose nonfermenting 1-related kinase; Trib3: tribbles homologue 3; PPARα: peroxisome proliferator-activated receptor α; UCP3: uncoupling protein 3; ACC: Acetyl-coA carboxylase; AMPK: adenosine monophosphate-activated protein kinase; ROCK: Rho-associated kinase; ERK: extracellular-signal-regulated kinase; IL-10: interleukin 10; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; IL-6: interleukin 6; TNF-α: tumor necrosis factor α; PRDM16: PR domain containing 16; UCP1: uncoupling protein 1; PGC1α: peroxisome proliferator-activated receptor-γ co-activator 1α; PPP25RD: protein phosphatase 2 regulatory subunit B’Delta; mTOR: mammalian target of rapamycin; AKT: protein kinase B