fig5

Figure 5. Schematic representation of cancer treatment with anticancer drug-loaded liposome-micro-bubble complexes (PLMC) assisted by ultrasound (US). A: when flowing through the target region, drugs remain attached to the lipid shells of MBs but are unable to cross the tumour vasculature by simple diffusion; B: application of high-intensity focused US bursts the micro-bubbles to release drugs. The cavitating and imploding MBs also enhance permeability of the plasma membrane, leading to higher uptake of released drugs. MBs: micro-bubbles