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Vessel Plus 2022;6:[Accepted].10.20517/2574-1209.2022.35© The Author(s) 2022
Accepted Manuscript
Open AccessReview

A novel insight into the nature of modified LDL and their role in atherosclerosis 

Correspondence Address: Dmitry A. Kashirskikh, Institute for Atherosclerosis Research, 121609, Moscow, Russia; Shuzhen Guo, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China. E-mail:dim.kashirsckih@gmail.com

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© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Abstract

Atherosclerosis plays a major role in the development of cardiovascular diseases (CVDs), that are the leading cause of death worldwide. Modification of low-density lipoproteins (LDL) is considered to be one of the key events in atherogenesis. Native LDL undergoes multiple modifications in the human body that can lead to the formation of atherogenic modified LDL. Modifications of LDL change their physicochemical and biological properties. Possible modifications include changes in the structure, size, charge and composition of the lipoprotein particle. In addition, uptake and utilization of modified LDL is impaired in cells. Macrophages uptake modified LDL, that promotes the formation of foam cells, which are one of the key cellular components of atherosclerotic lesions. Nevertheless, the direct role of each atherogenic LDL modification in atherogenesis remains uncertain. This review has attempted to highlight the most important atherogenic modifications of LDL, such as oxidized, enzyme-modified non-oxidative, desialylated, glycated and carbamylated LDL. Studying the role of each type of LDL modifications would not only clarify the unknown parts of the atherosclerosis progression, but also allow to develop effective methods for its diagnosis, treatment and prevention. 

Cite This Article

Kashirskikh DA, Guo S, Panyod S, Chicherina NR, Ekta MB, Bogatyreva AI, Grechko AV. A novel insight into the nature of modified LDL and their role in atherosclerosis. Vessel Plus 2022;6:[Accept]. http://dx.doi.org/10.20517/2574-1209.2022.35

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