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Vessel Plus 2022;6:27. 10.20517/2574-1209.2021.135 © The Author(s) 2022.
Open Access Editorial

Current status and future prospects of percutaneous treatment of mitral valve disease: repair vs. replacement

Interventional Cardiology Unit, Cardiovascular Institute, Hospital Clinic, University of Barcelona, Barcelona 08036, Spain.

Correspondence to: Prof. Manel Sabaté, Interventional Cardiology Unit, Cardiovascular Institute, Hospital Clinic, University of Barcelona, C/Villarroel 170, Barcelona 08036, Spain. E-mail: masabate@clinic.cat

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    Academic Editor: Alexander D. Verin | Copy Editor: Xi-Jun Chen | Production Editor: Xi-Jun Chen

    © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

    After a hesitant start, transcatheter treatment of mitral valve disease is now rapidly evolving. Technical advancements have made percutaneous treatment a reality. While edge-to-edge repair is a consolidated procedure with demonstrated clinical efficacy, development of percutaneous mitral valves is relatively more cumbersome. In this special issue, we have selected five interesting papers that will shed light on this topic. Cepas-Guillen et al.[1] reviewed current techniques to repair (e.g., leaflet repair, annuloplasty systems, and chordae repair) or replace mitral valve (e.g., percutaneous prothesis) in the context of severe regurgitation. Scotti et al.[2] described the clinical, anatomical, and technical factors in selecting patients for either valve repair or replacement procedure. Furthermore, the authors provided with a practical algorithm to help in the selection process of different techniques. Spieker et al.[3] demonstrated the benefit of edge-to-edge repair in patients in whom the handgrip manoeuvre unmasked a severe mitral regurgitation. Echarte-Morales et al.[4] reviewed the different techniques used to treat mitral regurgitation following failed surgical valve repair or replacement.

    In this regard, mitral paravalvular leak closure and percutaneous mitral valve-in-valve procedures were presented. Finally, Nappi et al.[5] focused on emerging transcatheter mitral valve replacement devices as therapeutic options for degenerated mitral bioprosthesis or failed mitral repair. In that paper the authors summarized current interventional techniques and available evidence and compared outcomes between transcatheter technologies and reoperative mitral valve surgery. Additionally, practical algorithms to decide the type of surgical procedures (i.e., sternotomy vs. minimally invasive surgery with right thoracotomy) and to select between transcatheter intervention and re-do surgery were also provided.

    I truly believe that the reader will enjoy this special issue of Vessel Plus and find it very useful in understanding current techniques and future prospects in this field.


    Authors’ contributions

    The author contributed solely to this article.

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    Financial support and sponsorship


    Conflicts of interest

    The author declared that they are bound by confidentiality agreements that prevent them from disclosing their conflicts of interest in this work.

    Ethical approval and consent to participate

    Not applicable.

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    Not applicable.


    © The Author(s) 2022.


    • 1. Cepas-Guillen PL, Flores-Umanzor E, Regueiro A, Freixa X. Percutaneous treatment of mitral valve disease: repair vs. replacement. Vessel Plus 2021;5:2.

    • 2. Scotti A, Galasso M, Margonato A, Godino C. Patient selection for trans-catheter mitral valve repair vs. replacement: ongoing indications and glimpse to the future. Vessel Plus 2021;5:6.

    • 3. Spieker M, Hellhammer K, Spießhoefer J, et al. Percutaneous mitral valve repair with the MitraClip in patients with handgrip exercise-induced dynamic mitral regurgitation. Vessel Plus 2020;4:29.

    • 4. Echarte-Morales J, Minguito-Carazo C, Benito-González T, et al. Percutaneous treatment of mitral regurgitation recurrence after mitral valve surgery. Vessel Plus 2021;5:54.

    • 5. Nappi F, Verghi E, Singh SSA, et al. Transcatheter valve-in-valve implantation vs. reoperative mitral valve surgery for failing surgical prosthesis. Vessel Plus 2021;5:40.


    Cite This Article

    Sabaté M. Current status and future prospects of percutaneous treatment of mitral valve disease: repair vs. replacement. Vessel Plus 2022;6:27. http://dx.doi.org/10.20517/2574-1209.2021.135



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