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Vessel Plus 2022;6:[Accepted].10.20517/2574-1209.2021.89@The Author(s) 2022
Accepted Manuscript
Open AccessReview

Cardiovascular involvement in multisystem inflammatory syndrome in children with COVID-19 

Correspondence Address: Gautam Singh, Division of Pediatric Cardiology, Children’s Hospital of Michigan, Central Michigan University College of Medicine, 3901 Beaubien Blvd, Detroit, MI 48201, USA. E-mail: Gsingh3@dmc.org


© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.


In children, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections typically result in a less severe coronavirus 19 (COVID-19) presentation than in adults. However, a subset of children presents with severe multisystem inflammation associated with recent SARS-CoV-2 infection or COVID-19 exposure in the previous weeks. The Center for Disease Control (CDC) has termed this condition a Multisystem Inflammatory Syndrome in Children (MIS-C). MIS-C causes significant cardiovascular involvement, which can be a determinant of clinical course and outcomes. A subset of MIS-C patients presents with hypotension and shock either from acute myocardial dysfunction or systemic vasodilation, with at least of third of patients developing cardiac manifestations from the illness. In addition, myocarditis, pericarditis, valvular regurgitation, coronary artery involvement, and arrhythmias have been reported, with a smaller subset of patients requiring extracorporeal membrane oxygenation. Here, we report our institutional experience of MIS-C over the last year and present a narrative review of cases reported in the literature. In addition, we discuss the clinical protocol of diagnosis and acute and follow-up management of these patients with MIS-C. 

Cite This Article

Misra A, Safa R, Sanil Y, Blake JM, Charaf Eddine A, Balakrishnan P, Garcia RU, Aggarwal S, Singh G. Cardiovascular involvement in multisystem inflammatory syndrome in children with COVID-19. Vessel Plus 2022;6:[Accept]. http://dx.doi.org/10.20517/2574-1209.2021.89

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