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Vessel Plus 2021;5:[Accepted].10.20517/2574-1209.2021.69@The Author(s) 2021
Accepted Manuscript
Open AccessReview

Interpreting signals from the peripheral nerve in amyloidosis: a call for action

Correspondence Address: Dr. Lorenzo Verriello, Neurology Unit, Department of Neurosciences, Santa Maria della Misericordia University Hospital, ASUFC, Piazzale Santa Maria della Misericordia 15, Udine 33100, Italy. E-mail: lorenzo.verriello@asufc.sanita.fvg.it


© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.


Systemic amyloidosis includes a group of disorders, characterized by deposition of insoluble aggregates of amyloid fibrils in various tissues that lead to the disruption of normal tissue structure and function. They are currently categorized as hereditary and secondary. Peripheral neuropathy is a frequent complication of systemic amyloidosis. The most common phenotype is a length-dependent sensorimotor polyneuropathy with autonomic dysfunction, but there are many atypical presentations that often lead to delayed diagnosis. In this review, we emphasize the neurological clinical aspects that induce a suspicion of amyloidosis, the possible differential diagnosis and the diagnostic pitfalls. An early recognition of the disease is crucial for starting quickly an appropriate treatment, that may change the course and the progression of the disease.

Cite This Article

Verriello L, Torre CD, Pauletto G, Gigli GL. Interpreting signals from the peripheral nerve in amyloidosis: a call for action. Vessel Plus 2021;5:[Accept]. http://dx.doi.org/10.20517/2574-1209.2021.69

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