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Vessel Plus 2021;5:[Accepted].10.20517/2574-1209.2021.52@The Author(s) 2021
Accepted Manuscript
Open AccessReview

ENT manifestations of granulomatosis with polyangiitis

Correspondence Address: Dr. Mohamed Tharwat Hegazy, MD, Internal Medicine Department, Rheumatology, and Clinical Immunology Unit, Faculty of Medicine, Cairo University, Al Kasr Al Ainy street, El Manial, Cairo, Cairo 11562, Egypt. E-mail: dr_moh_tharwat@kasralainy.edu.eg


© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.


Ear, nose, and throat (ENT) symptoms represent the most frequent manifestations at the onset of granulomatosis with polyangiitis (GPA). The diagnosis of the localized form of GPA remains challenging thus contributing to the delay at the beginning of treatment. This could lead to major sequelae due to tissue destruction. Otolaryngologists play a key role in collaboration with rheumatologists in early GPA diagnosis and treatment. Clinicians should maintain a high index of suspicion and proceed to a more comprehensive evaluation in cases of imperfect response to treatment or with unexplained atypical findings. The challenging issue in localized organ involvement during GPA is to determine whether the non-specific local upper aerodigestive symptoms are caused by a specific or a non-specific inflammatory process. The role of surgery becomes crucial in cases of laryngeal involvement. Life-threatening airway compromise necessitates urgent surgical intervention. There is an emerging role in the local ENT therapies.

Cite This Article

Hegazy MT, Ahmed H, Eltelety AM. ENT manifestations of granulomatosis with polyangiitis. Vessel Plus 2021;5:[Accept]. http://dx.doi.org/10.20517/2574-1209.2021.52

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