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Vessel Plus 2021;5:[Accepted].10.20517/2574-1209.2021.41@The Author(s) 2021
Accepted Manuscript
Open AccessReview

Ear, nose and throat in ANCA-associated vasculitis: a comprehensive review 

Correspondence Address: Dr. Roberto Padoan, Rheumatology Unit, University of Padova, Via Giustiniani, 2, 35128 Padova, Italy. E-mail: robertopadoan.reumatologia@gmail.com


© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.


Ear, nose and throat (ENT) involvement is a common feature in ANCA-associated vasculitis (AAV), particularly in granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA). Over the last decade, substantial advance has been made in understanding AAV pathogenesis, classification, and treatment. Typical ENT symptoms may include sinonasal, otologic, pharyngeal, and laryngeal manifestations. The otolaryngologic symptoms of AAV sometimes might be misdiagnosed in aetiology as infectious or allergic. Thus, rapid recognition and early diagnosis of AAV as the cause of the symptoms prevent the risk of irreversible organ damage. The high impact of ENT symptoms on quality of life of AAV patients confirms the importance of their early treatment through specific local and systemic approach. Appropriate interdisciplinary management to early recognition of AAV and initiation of treatment may reduce morbidity in these patients. The purpose of this comprehensive review is to describe the clinical, histologic and radiological findings of ENT involvement in AAV, and to update their surgical and therapeutic management, with a focus also on the role of a multidisciplinary team, involving the otorhinolaryngologist. 

Cite This Article

Padoan R, Campaniello D, Felicetti M, Cazzador D, Schiavon F. Ear, nose and throat in ANCA-associated vasculitis: a comprehensive review. Vessel Plus 2021;5:[Accept]. http://dx.doi.org/10.20517/2574-1209.2021.41 

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