1Department of Surgery, Division of Trauma Surgery and Surgical Critical Care, Creighton University School of Medicine, Omaha, NE 68131-2137, USA.
2Department of Radiology, Creighton University School of Medicine, Omaha, NE 68131-2137, USA.
Correspondence Address: Dr. Juan Antonio Asensio, Department of Surgery, Division of Trauma Surgery and Surgical Critical Care, Creighton University School of Medicine, 601 North 30th Street, Suite 3701, Omaha, NE 68131-2137, USA. E-mail: JuanAsensio@creighton.edu
Dr. Juan Antonio Asensio currently serves as Professor and Vice-Chairman of the Department of Surgery of Creighton University (With Tenure). He has been tenured at four other universities. He is also the Chief of the Division of Trauma Surgery and Surgical Care. He is the Director of the Trauma Center and Trauma Program and Creighton University Hospital. He is the Professor of Clinical and Translational Science Creighton University Medical School. He is also appointed as Professor of Surgery Adjunct, Uniform Services University of the Health Sciences (USUHS), F. Edward Hebert School of Medicine, Bethesda, Maryland.
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While vertebral artery injuries are uncommon, they can have significant morbidity if not identified and treated in a timely fashion. While the majority of vertebral artery injuries are the result of blunt injury and typically have favorable outcomes, a substantial percentage of patients with penetrating injury to the neck may also have vertebral artery injury necessitating angiographic or operative intervention. A 45-year-old male sustained a single stab wound to the apex of the posterior triangle of the neck, below the left mastoid process. At the scene, Emergency Medical Services personnel reported large blood loss and upon arrival, his initial vital signs were consistent with Class II/III hemorrhagic shock. Physical examination revealed a 9 cm longitudinal and deep laceration which began to bleed rapidly and profusely during his inital evaluation. The patient was intubated and rapidly transported to the operating room for exploration of the wound with direct control of the suspected vascular injury via suture ligation and application of vascular clips and to interventional radiology suite for embolization. Operative control was necessary however, immediate post-operative angiography allowed confirmation of collateral cerebral perfusion. The patient had an uneventful recovery and was evaluated in the Trauma Clinic during his 7, 14, 30 and 60-day follow-up.
Vertebral artery, stab wound, vertebral artery injuries
The vertebral artery is located deep within the neck therefore, it is rarely injured. An epidemiology study by Hsu et al. identified 14 cases, 0.08% of vertebral artery injuries in a multi-institutional database of 16,582 patients, a prevalence rate of 8.4 per 10,000. When examining penetrating trauma to the neck, the incidence has been reported as between 1.0-7.4%, with some variation attributed to mechanism (gunshot wound versus stab wound). Some believe however, that the low incidence of vertebral artery injuries previously reported is due to inefficient diagnostic tools, before the advent of routine angiography in penetrating neck trauma.[3,4] Even with angiography, there are variations in vertebral artery anatomy that should be taken into consideration. Preoperative imaging revealed anomalous variations in 50% of patients with vertebral artery injuries, in a multicenter study. With increasing incidence of vertebral artery injury in patients with cervical spine trauma, vertebral artery injuries should be ruled out in patients presenting with neck and cervical spine trauma. Early diagnosis and intervention is critical to successful management of vertebral artery injuries. Multiple complications result from these types of injuries, and the point of entry and exit of the foreign object in penetrating injuries to the neck could predict susceptibility to injury and outcome.[5,7]
In a prospective study by Jang et al., none of the patients experienced secondary neurologic deterioration from vertebrobasilar ischemia, similarly the patient in this case report also did not develop neurologic sequelae. Other studies have also shown that with proper management, patients experience uneventful recovery without residual effects. While neurologic deficits are rare complications of vertebral artery injury, when neurologic deficit occurs, they could be devastating and permanent. Other severe outcomes are complications of stroke, pseudoaneurysm, late-onset hemorrhage, brain stem and cerebellar infarcts, and death;[1,5,8,9] early diagnosis and management are therefore critical to positive outcome.
This case report aims to describe the roles of surgical procedures and interventional radiology in the successful management of emergent vertebral artery injuries.
A 45-year-old male who sustained a single stab wound at the apex of the posterior triangle of the neck below the left mastoid process was transported to the level 1 trauma center by Emergency Medical Services personnel, who reported large blood loss at the scene. Upon arrival, the patient’s initial vital signs were: blood pressure (BP) 106/51 mmHg, pulse 139 bpm. Physical examination revealed a 9-cm longitudinal deep laceration with no active bleeding and the interventional radiologist was consulted. Subsequently, the wound began to bleed rapidly and profusely. Pressure was applied. The patient was intubated; massive transfusion protocol was activated and the patient was rapidly transported to the operating room (OR).
In the OR, the wound was explored by enlarging the incision longitudinally, and interventional radiology (IR) was contacted. Ideally, the patient should have gone directly to IR suite upon his admission. Unfortunately, the patient began to bleed significantly, thus precluding this option. IR however, had already been consulted. In the OR, the goal was to obtain hemostasis through direct control of the vessel; however, the location of the injury at the skull base precluded this. Temporary control in the OR was therefore obtained.
In the OR, the sternocleidomastoid was partially transected. Bleeding was controlled from muscular arterial and venous branches. A deeper wound track in the anteromedial aspect of wound was partially explored and bleeding was controlled. The sternocleidomastoid was re-approximated and the wound was closed. Estimated blood loss (EBL) was 1,100 mL. Total fluid replacement was 3,900 mL: crystalloids 2,700 mL and 4 units packed red blood cells (PRBCs) 1,200 mL.
The patient was transported to the intensive care unit (ICU) pending IR arrival. Immediately upon arrival, the patient became hypotensive with a systolic BP - 55 mmHg. He bled massively. Digital control was established and he was returned to the OR.
Senior trauma surgery staff was paged signal transducer and activator of transcription to the OR. The patient was then re-explored. The longitudinal incision was extended and the sternocleidomastoid muscle was completely transected along with the splenius capitis muscle. Transverse processes of C1-C2 were palpated and the pre-vertebral fascia was entered. The vertebral artery at V3 (third portion) was noted to be partially transected extracranially; it was controlled with vascular clips. Paired vertebral veins were controlled in the same fashion. Hemorrhage was thus controlled. The accessory spinal nerve was not visualized. Bone wax was applied and the wound closed. EBL was 3,000 mL. Total volume replacement was 6,400 mL: crystalloids 4,000 mL, 6 units PRBCs 1,800 mL, 2 units fresh frozen plasma 600 mL.
During the second intervention, a more complete exploration identified the injury thus allowing for definitive control.
Angiographic visualization of the vasculature was performed by catheter angiography, which revealed that complete acute occlusion of the left vertebral artery at the C1-C2 level was successfully achieved during the second surgical intervention [Figure 1]. The catheterization of the right vertebral artery showed normal perfusion with opacification of the very distal segment of the left vertebral artery. The late phase of angiography depicted a pattern consistent with an extra-dural pseudoaneurysm noted above the surgically placed clips.
Figure 1. Vertebral artery surgically controlled prior to embolization (A) and digital subtraction shadow of surgically applied clips (B)
The first step during angiography included endovascular embolization by coils of the left vertebral artery proximal to the visualized surgical occlusion. The second stage proceeded by navigation of the micro-catheter through the right vertebral artery in retrograde fashion into the very distal part of the left vertebral artery with navigation of the catheter tip above the level of the surgically placed clips [Figure 2]. Embolization in this location was performed again by lumen occlusion with coils with meticulous preservation of the anterior spinal artery, which had its origin from the distal left vertebral artery. The territory of the left posterior inferior cerebellar artery was satisfactory collateralized by the left anterior inferior cerebellar artery. Thus, this endovascular approach obtained complete proximal and distal trapping of the left vertebral artery pseudoaneurysm above the surgically placed clips [Figure 3].
Figure 2. Right vertebral artery angiography after embolization by coils of the very proximal part of left vertebral artery (arrow showing coils, B). Retrograde opacity of the distal left vertebral artery shows persistent extravasation of contrast with an extradural pseudoaneurysm above the surgically placed clips which had controlled all bleeding operatively (A) secondary to vessel transection from the stab wound
Figure 3. The micro catheter was placed in retrograde fashion in the left distal vertebral artery immediately above the extradural pseudoaneurysm during deployment. Endovascular approach obtained complete proximal (A) and distal (B) trapping of the extra dural left vertebral artery pseudoaneurysm above the surgical clips
The patient was transferred to the ICU, extubated on the second post-operative day and transferred to the floor. He was observed for 2 days and discharged on post-operative day 4. No problems were noted with balance when ambulating. He had an uneventful recovery. He was evaluated in the Trauma Clinic during his 7, 14, 30 and 60-day follow-up with no sequelae noted from this rare and complex vascular injury.
Penetrating vertebral artery injuries are rare and their injuries were previously missed prior to the routine use of angiography in diagnosing penetrating neck injuries.
This patient specifically, sustained a penetrating injury to the vertebral artery and had hard signs of vascular injury with profuse bleeding at the scene and upon examination of the wound during his initial evaluation. This is the most common presentation in penetrating vertebral artery injury at 50%, while 30% present only with soft signs, and 20% with no overt signs. This frank hemorrhage was the impetus for the decision for operative exploration at the onset. This decision also corresponds to the algorithm suggested by Greer et al. in their series of penetrating vertebral artery injuries managed during the military campaigns in Iraq and Afghanistan. Early operative intervention was also recommended by Reid and Weigelt in their series of 43 patients from 1976-1986; both series agree that patients without acute life-threatening injuries can be safely evaluated without imaging studies (computed tomography angiography, digital subtraction angiography) with minimal risk to the patient.
Vertebral artery injuries though uncommon, could be fatal. Operative management is difficult and requires significant experience, in some cases, definitive control can be achieved through endovascular embolization by interventional radiology. While these approaches are described in the literature, there is little data on the multimodal therapy provided in this patient’s care. Operative control was necessary however, immediate post-operative angiography allowed confirmation of collateral cerebral perfusion. The use of coil embolization in addition to ligation may also decrease the risk of post-operative morbidity such as fistula formation, re-bleeding, and pseudoaneurysm formation. Additional investigation of this approach is therefore warranted.
Study conception and design: J.A. Asensio
Analysis and interpretation of data: R. Bertellotti, O.A. Ogun, A. Mironov, J.A. Asensio
Drafting of manuscript: R. Bertellotti, O.A. Ogun
Critical revision: R. Bertellotti, O.A. Ogun, A. Mironov, J.A. AsensioFinancial support and sponsorship
None.Conflicts of interest
There are no conflicts of interest.Patient consent
Not applicable as there is no identifying data.Ethics approval
Not required for this type of publication in our institution.
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