Topic: Atherosclerosis, Diabetes Mellitus, and Metabolic Syndrome: Commonalities and Differences in Phenotypes, Metabolic Pathways and Genetics

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A special issue of Vessel Plus (Online ISSN:2574-1209).

Deadline for manuscript submissions: 31 Aug 2018

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Guest Editor(s)

  • Dr. Igor A. Sobenin, PhD
    Institute of Experimental Cardiology, National Medical Research Center of Cardiology, Moscow, Russia.

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Special Issue Introduction:

Atherosclerosis and metabolic disturbances like excessive body mass, obesity, metabolic syndrome and type 2 diabetes mellitus are widely spread and represent the pathologies affecting most of the aged population; they often develop in parallel and, thus, form the comorbidity. Clustering of obesity, conventional cardiovascular risk factors, atherosclerosis, coronary artery disease, type 2 diabetes mellitus is observed both in epidemiological and clinical studies. Each of common risk factors individually explains an increased risk of clinical manifestations of disease, and the presence of multiple risk factors is translated into the higher integral risk level. This is well supported by the concept of constellation of several risk factors that confers an elevated integral risk of cardiometabolic abnormalities and atherosclerotic disease. Most of conventional risk factors are shared by atherosclerosis and metabolic diseases, but the genetic and metabolic mechanisms may differ, thus subdividing into common and disease-specific ones. It is well recognized that common risk factors are characterized by a significant genetic component, but there are evident uncertainties on the role of genetic factors in risk factor clustering in individuals. The complexity of phenotypes should be also taken into account, as well as uncertainty about the common pathogenetic mechanisms explaining the clustering of cardiometabolic abnormalities and disease development, as well as modulating effects of lifestyle factors.
The present special issue aims to provide contributions related to the recent fundamental, generalized and clinical findings that would integrate research data, aimed to evaluation of atherosclerosis-related and metabolic pathologies, and even for finding molecular and pathway targets for further development of pathogenesis-targeted therapy.


Atherosclerosis, type 2 diabetes mellitus, metabolic syndrome, obesity, metabolism, genetics, risk factors, pathogenesis

Submission Information:

Articles of special issue are free of charge for article processing.
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Submission Deadline: 31 Aug 2018
Contacts: Sylvia Wang, Managing Editor,

Published Articles Download All Articles
  • Age-associated features of oxidative stress as marker of vascular aging in comorbid course of hypertension and type 2 diabetes mellitus

    Valeriya Nemtsova , Olexander Bilovol , Irina Ilchenko , Anna Shalimova
    Aim: To evaluate activity of oxidative stress (OS) as marker of vascular aging in different age groups of patients with combined course of arterial hypertension (HT) and type 2 diabetes mellitus (T2DM). Methods: 126 patients (average age 57.8 ± 6.2 years) with stage II HT and compensated T2DM were divided into 2 subgroups: 2a (n = 59) - aged 45-60 years; 2b (n = 97) - aged 61-75 years; 30... Read more
    This article belongs to the Special Issue Atherosclerosis, Diabetes Mellitus, and Metabolic Syndrome: Commonalities and Differences in Phenotypes, Metabolic Pathways and Genetics
    Vessel Plus 2018;2:27. | doi:10.20517/2574-1209.2018.48
    Published on: 28 Sep 2018  | Viewed:145  | Downloaded:8
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