Topic: Atherosclerosis and Related Diseases

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A special issue of Vessel Plus (Online ISSN:2574-1209).

Deadline for manuscript submissions: 19 Sep 2017

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Guest Editor(s)

  • Prof. Alexander N. Orekhov, PhD
    Institute of General Pathology and Pathophysiology, Moscow, Russia.
    Director, Institute for Atherosclerosis Research (Skolkovo), Moscow, Russia.

    Website | E-mail

Special Issue Introduction:

Atherosclerosis and atherosclerotic diseases remain the problem number one of current medicine and health care being the cause of myocardial infarction, stroke, sudden death, and other common causes of mortality and disability. Atherosclerotic diseases account for more than 50% of total mortality in industrialized societies. Atherosclerotic lesion development has a long asymptomatic phase. Therefore, in many cases first clinical manifestations of atherosclerosis appear when the lesion is already well developed causing significant narrowing of the vascular lumen. Current treatment of atherosclerosis is mainly symptomatic and does not affect the atherosclerotic lesion per se. Frequently, symptomatic therapy that improves the state of the patient even provokes further development of atherosclerosis. Unfortunately, direct anti-atherosclerotic therapy aimed at regression of atherosclerotic plaques remains to be developed. Such development should become a major goal of modern medicine and pharmaceutical industry, taking into account the burden and clinical significance of the disease.
The development of novel anti-atherosclerotic therapies is hindered by the lack of knowledge of the disease mechanisms and the absence of comprehensive concepts of the disease pathogenesis. Detailed studying of the disease mechanisms at molecular and cellular level using modern methods of analysis should attempt to solve this problem. Among the mechanisms to be studied at the first place, are lipid metabolism, innate immunity, chronic inflammation and cell differentiation. In addition to the traditional methods of morphology and biochemistry, the most advanced techniques of cellular and molecular biology should be applied. The results of these studies should contribute to the development of novel comprehensive concepts of the pathogenesis of atherosclerosis and to identification of novel pharmacological tagets for direct anti-atherosclerotic therapy. During the recent years, in addition to the widely-accepted lipid concept of atherogenesis, new targets for anti-atherosclerotic therapy associated with innate immunity and inflammation were proposed.

Keywords:

Atherosclerosis, atherosclerotic diseases, low density lipoprotein (LDL), diabetes mellitus

Submission Information:

Articles of special issue are free of charge for article processing.
For Author Instructions, please refer to http://vpjournal.net/pages/view/author_instructions
For Online Submission, please login at http://vpjournal.net/login
Submission Deadline: 19 Sep 2017
Contacts: Sylvia Wang, Managing Editor, editorialoffice@vpjournal.net

Published Articles Download All Articles
  • HDL subfraction distribution and HDL function in untreated dyslipidemic patients

    Mariann Harangi , Anita Szentpéteri , Bíborka Nádró , Hajnalka Lőrincz , Ildikó Seres , Dénes Páll , György Paragh
    Aim: The protective role of high-density lipoprotein (HDL) against atherosclerosis is well known. However, both structural and functional changes of the HDL particles may affect its protective efficacy. Increased levels of HDL-associated myeloperoxidase (MPO) and decreased HDL-linked paraoxonase-1 (PON1) activity have been reported in dyslipidemic patients. Some changes in HDL subfraction distributions were also studied previously, but data on structural and functional changes in dyslipidemia are not complete. Therefore, the authors aimed to evaluate these qualitative and quantitative... Read more
    Vessel Plus 2017;1:166-73. | doi:10.20517/2574-1209.2017.27
    Published on: 28 Dec 2017  | Viewed:1058  | Downloaded:73
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  • Is insulin pro-atherogenic at the cellular level?

    Igor A. Sobenin , Varvara A. Orekhova , Andrey V. Grechko , Alexander N. Orekhov
    Aim: This study was undertaken to test the hypothesis that insulin treatment has unexpected pro-atherogenic effects at the cellular level, namely, proliferative activity and intracellular cholesterol content. Methods: Primary cultures of subendothelial cells derived from non-atherosclerotic human aorta and mouse peritoneal macrophages were used to investigate the in vitro effect of insulin on atherosclerosis-related parameters, such as cellular cholesterol content and proliferation rate. Additionally, the effect of insulin treatment in 33 type 1 diabetic patients on serum atherogenicity... Read more
    Vessel Plus 2017;1:174-81. | doi:10.20517/2574-1209.2017.19
    Published on: 28 Dec 2017  | Viewed:971  | Downloaded:68
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  • New markers of atherosclerosis: a threshold level of heteroplasmy in mtDNA mutations

    Margarita A. Sazonova , Anastasia I. Ryzhkova , Vasily V. Sinyov , Elena V. Galitsyna , Varvara A. Orekhova , Alexandra A. Melnichenko , Alexander N. Orekhov , Alessio L. Ravani , Igor A. Sobenin
    Aim: The aim of the present article was the detection of threshold heteroplasmy level of mitochondrial DNA mutations, above which a patient is at increased risk of atherosclerotic lesions. Besides, this parameter was detected for mutations, in which after reaching threshold heteroplasmy level, a protective antiatherogenic effect started to appear. Methods: The participants of the study were 700 women and men from the Moscow region. Fragments of DNA, amplified by polymerase chain reaction, were analyzed with pyrosequencing technology. Then on the basis of pyrograms’ peaks in the samples, the... Read more
    Vessel Plus 2017;1:182-91. | doi:10.20517/2574-1209.2017.16
    Published on: 28 Dec 2017  | Viewed:1503  | Downloaded:87
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  • Relationship between peculiarities of atrial fibrillation, body mass index and adipokines levels

    Oleksandr Bilovol , Yuliya Shaposhnikova , Iryna Ilchenko , Anna Shalimova
    Aim: To assess the value of body mass index (BMI) and adipokine levels in predicting development of atrial fibrillation (AF) in the general population. Methods: Three hundred and ninety eight patients were examined for the presence of phenotype metabolically healthy obesity (MHO), according to the Wildman criteria; adipokine levels were assessed by enzyme immunoassay method; AF was assessed by electrocardiography (ECG) and/or by ECG diurnal monitoring. Results: Obesity (group 1) and overweight (group 2) was present in 23.7% and 42.0% of participants; while 21.1% were normal body weight... Read more
    Vessel Plus 2017;1:196-201. | doi:10.20517/2574-1209.2017.17
    Published on: 28 Dec 2017  | Viewed:1785  | Downloaded:75
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  • Proinflammatory monocyte polarization in type 2 diabetes mellitus and coronary heart disease

    Nikita G. Nikiforov , Karina O. Galstyan , Liudmila V. Nedosugova , Natalia V. Elizova , Kira I. Kolmychkova , Ekaterina A. Ivanova
    Aim: Type 2 diabetes mellitus (T2DM) is associated with rapid progression of atherosclerosis. There is no doubt that inflammation is involved in atherogenesis. Recent studies showed the relationship between the development of atherosclerotic plaque formation and the amount of pro-inflammatory (M1) activated macrophages in situ. Methods: The authors studied the ability of circulating monocytes isolated from patients with diabetes (n = 28), coronary heart disease (CHD) (n = 27) and healthy subjects (n = 50) to be activated into M1 phenotype in vitro. Results: Increased levels of basal and... Read more
    Vessel Plus 2017;1:192-5. | doi:10.20517/2574-1209.2017.21
    Published on: 28 Dec 2017  | Viewed:973  | Downloaded:81
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  • Introduction of the special issue “Atherosclerosis and Related Diseases”

    Alexander N. Orekhov , Ekaterina A. Ivanova
    Vessel Plus 2017;1:163-5. | doi:10.20517/2574-1209.2017.33
    Published on: 28 Dec 2017  | Viewed:443  | Downloaded:49
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  • A prominent role of D-dimer in inflammation and atherosclerosis

    Veronika A. Myasoedova , Paolo Poggio , Alessandro Parolari
    Vessel Plus 2017;1:96-7. | doi:10.20517/2574-1209.2017.22
    Published on: 26 Sep 2017  | Viewed:555  | Downloaded:68
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  • Associations of lifestyle and dietary habits with hyperlipidemia in Lebanon

    Ali A. Samaha , Fouad Zouein , Maya Gebbawi , Mirna Fawaz , Raheel Houjayri , Rana Samaha , Safaa Baydoun , Ali H. Eid
    Aim: This study was designed to evaluate the effects of dietary and lifestyle habits on several blood lipid parameters in the Lebanese population. Methods: This was a cross-sectional study for 2,000 individuals, of whom 1,003 completed the survey about their dietary and lifestyle habits. Anthropometric measurements and blood tests were performed and recorded. Results: Up to 53.2% of the population was hypercholesterolemic. Gender and age contributed to the prevalence of high levels of low density lipoprotein cholesterol (LDL-C) or triglycerides. Prevalence of hypercholesterolemia,... Read more
    Vessel Plus 2017;1:98-106. | doi:10.20517/2574-1209.2017.18
    Published on: 26 Sep 2017  | Viewed:1317  | Downloaded:119
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  • Chemical composition of circulating native and desialylated low density lipoprotein: what is the difference?

    Vladimir I. Alipov , Vasily N. Sukhorukov , Vasily P. Karagodin , Andrey V. Grechko , Alexander N. Orekhov
    Atherosclerosis and related cardiovascular disorders remain the leading global cause of morbidity and mortality. Modified low density lipoprotein (LDL) is considered to play a crucial role in atherosclerosis development. During the past decades, several types of atherogenic LDL modification have been discovered. Desialylation was one of the atherogenic modifications observed in circulating atherogenic LDL in vivo. Sialic acid level negatively correlates with triglyceride and cholesterol contents. Desialylated LDL is small, dense and highly susceptible to oxidation, as reported for... Read more
    Vessel Plus 2017;1:107-15. | doi:10.20517/2574-1209.2017.20
    Published on: 26 Sep 2017  | Viewed:1087  | Downloaded:91
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Vessel Plus ISSN 2574-1209 (Online)
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