Published Special Issues
Topic: Atherosclerosis and Related Diseases
  • A prominent role of D-dimer in inflammation and atherosclerosis

    Veronika A. Myasoedova , Paolo Poggio , Alessandro Parolari
    Vessel Plus 2017;1:96-7. | doi:10.20517/2574-1209.2017.22
    Published on: 26 Sep 2017  | Viewed:136  | Downloaded:20
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  • Is insulin pro-atherogenic at the cellular level?

    Igor A. Sobenin , Varvara A. Orekhova , Andrey V. Grechko , Alexander N. Orekhov
    Aim: This study was undertaken to test the hypothesis that insulin treatment has unexpected pro-atherogenic effects at the cellular level, namely, proliferative activity and intracellular cholesterol content. Methods: Primary cultures of subendothelial cells derived from non-atherosclerotic human aorta and mouse peritoneal macrophages were used to investigate the in vitro effect of insulin on atherosclerosis-related parameters, such as cellular cholesterol content and proliferation rate. Additionally, the effect of insulin treatment in 33 type 1 diabetic patients on serum atherogenicity... Read more
    Vessel Plus 2017;1:. | doi:10.20517/2574-1209.2017.19
    Published on: 17 Oct 2017  | Viewed:65  | Downloaded:5
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  • Associations of lifestyle and dietary habits with hyperlipidemia in Lebanon

    Ali A. Samaha , Fouad Zouein , Maya Gebbawi , Mirna Fawaz , Raheel Houjayri , Rana Samaha , Safaa Baydoun , Ali H. Eid
    Aim: This study was designed to evaluate the effects of dietary and lifestyle habits on several blood lipid parameters in the Lebanese population. Methods: This was a cross-sectional study for 2,000 individuals, of whom 1,003 completed the survey about their dietary and lifestyle habits. Anthropometric measurements and blood tests were performed and recorded. Results: Up to 53.2% of the population was hypercholesterolemic. Gender and age contributed to the prevalence of high levels of low density lipoprotein cholesterol (LDL-C) or triglycerides. Prevalence of hypercholesterolemia,... Read more
    Vessel Plus 2017;1:98-106. | doi:10.20517/2574-1209.2017.18
    Published on: 26 Sep 2017  | Viewed:307  | Downloaded:21
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  • New markers of atherosclerosis: a threshold level of heteroplasmy in mtDNA mutations

    Margarita A. Sazonova , Anastasia I. Ryzhkova , Vasily V. Sinyov , Elena V. Galitsyna , Varvara A. Orekhova , Alexandra A. Melnichenko , Alexander N. Orekhov , Alessio L. Ravani , Igor A. Sobenin
    Aim: The aim of the present article was the detection of threshold heteroplasmy level of mitochondrial DNA mutations, above which a patient is at increased risk of atherosclerotic lesions. Besides, this parameter was detected for mutations, in which after reaching threshold heteroplasmy level, a protective antiatherogenic effect started to appear. Methods: The participants of the study were 700 women and men from the Moscow region. Fragments of DNA, amplified by polymerase chain reaction, were analyzed with pyrosequencing technology. Then on the basis of pyrograms’ peaks in the samples, the... Read more
    Vessel Plus 2017;1:. | doi:10.20517/2574-1209.2017.16
    Published on: 19 Oct 2017  | Viewed:418  | Downloaded:16
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  • Chemical composition of circulating native and desialylated low density lipoprotein: what is the difference?

    Vladimir I. Alipov , Vasily N. Sukhorukov , Vasily P. Karagodin , Andrey V. Grechko , Alexander N. Orekhov
    Atherosclerosis and related cardiovascular disorders remain the leading global cause of morbidity and mortality. Modified low density lipoprotein (LDL) is considered to play a crucial role in atherosclerosis development. During the past decades, several types of atherogenic LDL modification have been discovered. Desialylation was one of the atherogenic modifications observed in circulating atherogenic LDL in vivo. Sialic acid level negatively correlates with triglyceride and cholesterol contents. Desialylated LDL is small, dense and highly susceptible to oxidation, as reported for... Read more
    Vessel Plus 2017;1:107-15. | doi:10.20517/2574-1209.2017.20
    Published on: 26 Sep 2017  | Viewed:333  | Downloaded:30
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  • Relationship between peculiarities of atrial fibrillation, body mass index and adipokines levels

    Oleksandr Bilovol , Yuliya Shaposhnikova , Iryna Ilchenko , Anna Shalimova
    Aim: To assess the value of body mass index (BMI) and adipokine levels in predicting development of atrial fibrillation (AF) in the general population. Methods: Three hundred and ninety eight patients were examined for the presence of phenotype metabolically healthy obesity (MHO), according to the Wildman criteria; adipokine levels were assessed by enzyme immunoassay method; AF was assessed by electrocardiography (ECG) and/or by ECG diurnal monitoring. Results: Obesity (group 1) and overweight (group 2) was present in 23.7% and 42.0% of participants; while 21.1% were normal body weight... Read more
    Vessel Plus 2017;1:. | doi:10.20517/2574-1209.2017.17
    Published on: 25 Oct 2017  | Viewed:131  | Downloaded:6
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  • Proinflammatory monocyte polarization in type 2 diabetes mellitus and coronary heart disease

    Nikita G. Nikiforov , Karina O. Galstyan , Liudmila V. Nedosugova , Natalia V. Elizova , Kira I. Kolmychkova , Ekaterina A. Ivanova
    Aim: Type 2 diabetes mellitus (T2DM) is associated with rapid progression of atherosclerosis. There is no doubt that inflammation is involved in atherogenesis. Recent studies showed the relationship between the development of atherosclerotic plaque formation and the amount of pro-inflammatory (M1) activated macrophages in situ. Methods: The authors studied the ability of circulating monocytes isolated from patients with diabetes (n = 28), coronary heart disease (CHD) (n = 27) and healthy subjects (n = 50) to be activated into M1 phenotype in vitro. Results: Increased levels of basal and... Read more
    Vessel Plus 2017;1:. | doi:10.20517/2574-1209.2017.21
    Published on: 14 Nov 2017  | Viewed:58  | Downloaded:5
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  • HDL subfraction distribution and HDL function in untreated dyslipidemic patients

    Mariann Harangi , Anita Szentpéteri , Bíborka Nádró , Hajnalka Lőrincz , Ildikó Seres , Dénes Páll , György Paragh
    Aim: The protective role of high-density lipoprotein (HDL) against atherosclerosis is well known. However, both structural and functional changes of the HDL particles may affect its protective efficacy. Increased levels of HDL-associated myeloperoxidase (MPO) and decreased HDL-linked paraoxonase-1 (PON1) activity have been reported in dyslipidemic patients. Some changes in HDL subfraction distributions were also studied previously, but data on structural and functional changes in dyslipidemia are not complete. Therefore, the authors aimed to evaluate these qualitative and quantitative... Read more
    Vessel Plus 2017;1:. | doi:10.20517/2574-1209.2017.27
    Published on: 21 Nov 2017  | Viewed:23  | Downloaded:2
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Vessel Plus Online ISSN: 2574-1209
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