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  • Review

    Blood purification in intensive care patients with multiple organ dysfunction syndrome and sepsis after cardiac surgery

    Michael Yaroustovsky , Marina Abramyan , Ekaterina Komardina , Helen Nazarova
    Extracorporeal blood purification is becoming increasingly important in intensive therapy for multiple organ dysfunction syndrome (MODS) and sepsis, considering all of their pathophysiological aspects. The results of treatment, particularly in children, considering their anatomical and physiological features, are related to the severity and progression of organ failure, the indications that are found, the choice of method, and the timely initiation of blood purification. Multiple organ support therapy is the aim of introducing and applying blood purification today. Various extracorporeal...
    First Published on: 22 Jun 2017
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  • Case Report

    LDL apheresis or PCSK9 inhibition? Sometimes we have to combine them

    Mariann Harangi , Lilla Juhász , Bíborka Nádró , József Balla , György Paragh
    This study presents the case of a female patient with severe heterozygous familial hypercholesterolemia. Despite the combined maximum dose oral treatment with rosuvastatin and ezetimibe, we found markedly elevated lipid parameters. Therefore, we indicated monthly selective low density lipoprotein (LDL) apheresis treatment using the Direct Adsorption of Lipoproteins system. After more than 2 years the lipid levels of the patients were still above the therapeutic goals. Finally, we completed the treatment by the inhibitor evolocumab biweekly. Further LDL cholesterol (LDL-C) reduction was...
    First Published on: 6 Jun 2017
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  • Original Article

    Galectin-3 as a potential biomarker of metabolic disorders and cardiovascular remodeling in patients with hypertension and type 2 diabetes

    Lesya Bobronnikova
    Aim: To determine the impact of galectin-3 levels on the progression of metabolic disorders and structural-functional changes in the myocardium and blood vessels in patients with concomitant systemic arterial hypertension (AH) and type 2 diabetes mellitus (type 2 DM). Methods: Ninety-five patients with hypertension stage II grade 2 (53 males and 42 females) were examined. The patients were separated: group 1 (n = 32) patients with AH, without carbohydrate metabolism disorders; group 2 (n = 30) patients with AH and pre-diabetes; group 3 (n = 33) concomitant AH and type 2 DM. Carbohydrate...
    First Published on: 26 May 2017
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  • Editorial

    Myocardial ischemia in women: problems and challenges

    Tamar Vakhtangadze , Nino Gakhokidze
    First Published on: 10 May 2017
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  • Original Article

    The effect of postoperative malperfusion after surgical treatment of type A acute aortic dissection on early and mid-term survival

    Paolo Nardi , Carlo Olevano , Carlo Bassano , Emanuele Bovio , Lorenzo Cecchetti , Stefano Forlani , Giovanni Ruvolo
    Aim: To evaluate whether postoperative malperfusion (PM) affected in-hospital and long-term survival in acute type A aortic dissection (AAAD) surgical patients and to identify risk factors for PM. Methods: Patients who underwent AAAD surgery at a single institution between January 2005 and March 2015 were retrospectively analyzed. Results: Two-hundred fourteen patients with complete data were identified. At presentation, 119 patients (55.6%) showed preoperative malperfusions: 68 (31.8%) were cerebral, 38 (17.7%) were renal, and 13 (6.1%) were mesenteric. PM was found in 55 patients (25.7%)....
    First Published on: 25 Apr 2017
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  • Original Article

    Initial experience with bioresorbable vascular scaffolds for percutaneous revascularisation in patients with acute coronary syndrome

    Alberto Cordero , Ramón López-Palop , Pilar Carrillo , Araceli Frutos , Clara Gunturiz , Maria García-Carrilero , Vicente Bertomeu-Martinez
    Aim: Bioresorbable vascular scaffolds (BVS) have recently been introduced to minimise the long-term complications of metallic stents in acute coronary syndrome (ACS), but their benefits have not been well analysed. Methods: The authors studied all ACS patients treated with any kind of stent at a single centre between March 2013 (when the first BVS was implanted) and June 2016. Results: The study included 951 subjects, mean age 67.9 ± 13.3 years, mean Global Registry of Acute Coronary Events (GRACE) score 148.5 ± 44.8, 75.2% men and 38.2% with an ST-segment elevation myocardial infarction....
    First Published on: 19 Apr 2017
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  • Case Report

    Leriche’s syndrome: a rare complication following anterior approach lumbar spinal surgery

    Ramyashree Tummala , Keyvan Ravakhah , Anjan Gupta
    Leriche’s syndrome is an aortic occlusive disease, which is due to obliteration of distal aorta above the site of bifurcation of common iliac arteries. The classic triad of symptoms include claudication, impotence, and absent or decreased femoral pulses. It may be acute or chronic in onset. Most of the cases are chronic in nature due to baseline pathophysiology involving atherosclerotic changes in the aorta. There are many causes of acute leriche’s syndrome like surgical manipulation, trauma, thromboembolic disease, hypercoagulability, atrial fibrillation, neoplasm, intraplaque hemorrhage...
    First Published on: 11 Apr 2017
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  • Short Communication

    Heart and vascular remodeling in essential hypertension and type 2 diabetes is dependent on genetic polymorphisms

    Anna Shalimova
    Aim: To study heart and vascular remodeling in essential hypertension (EH) and concomitant type 2 diabetes mellitus (DM2) with respect to genetic polymorphism of the angiotensin II receptor type 1 (AGTR1) gene and peroxisome proliferator-activated receptor-γ2 (PPARγ2). Methods: Biochemical blood analysis, echocardiographic evaluation of mitral diastolic blood flow and tissue Doppler spectral modes, reactive hyperemia, color Doppler mapping. Results: Patients with A/C and C/C genotypes of the AGTR1 gene had higher blood pressure, more pronounced metabolic disorders, a larger left ventricle...
    First Published on: 11 Apr 2017
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