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  • Review|Open Access

    Adipose tissue-derived cytokines, CTRPs as biomarkers and therapeutic targets in metabolism and the cardiovascular system

    Ya-Jing Wang , Jian-Li Zhao , Wayne Bond Lau , Jing Liu , Rui Guo , Xin-Liang Ma
    Increasing evidence indicates that adipose tissue-originated cytokines mediate communication between obesity-related exogenous molecules and the molecular events that initiate the metabolic syndrome and the inflammatory responses in the cardiovascular system (CVS). Adipose tissue-derived cytokines including the C1q/tumor necrosis factor-related proteins (CTRPs), a 15-member family of novel adipokines, has attracted much interest due to its metabolic regulatory and anti-inflammatory effect and appear to play a pathophysiological role in metabolism and immunity. To date, 15 members of CTRP... Read more
    Published on: 5 Dec 2017  | Viewed:110  | Downloaded:3
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    Introduction of the special issue “Atherosclerosis and Related Diseases”

    Alexander N. Orekhov , Ekaterina A. Ivanova
    Published on: 27 Nov 2017  | Viewed:47  | Downloaded:6
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    HDL subfraction distribution and HDL function in untreated dyslipidemic patients

    Mariann Harangi , Anita Szentpéteri , Bíborka Nádró , Hajnalka Lőrincz , Ildikó Seres , Dénes Páll , György Paragh
    Aim: The protective role of high-density lipoprotein (HDL) against atherosclerosis is well known. However, both structural and functional changes of the HDL particles may affect its protective efficacy. Increased levels of HDL-associated myeloperoxidase (MPO) and decreased HDL-linked paraoxonase-1 (PON1) activity have been reported in dyslipidemic patients. Some changes in HDL subfraction distributions were also studied previously, but data on structural and functional changes in dyslipidemia are not complete. Therefore, the authors aimed to evaluate these qualitative and quantitative... Read more
    Published on: 21 Nov 2017  | Viewed:51  | Downloaded:10
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    Proinflammatory monocyte polarization in type 2 diabetes mellitus and coronary heart disease

    Nikita G. Nikiforov , Karina O. Galstyan , Liudmila V. Nedosugova , Natalia V. Elizova , Kira I. Kolmychkova , Ekaterina A. Ivanova
    Aim: Type 2 diabetes mellitus (T2DM) is associated with rapid progression of atherosclerosis. There is no doubt that inflammation is involved in atherogenesis. Recent studies showed the relationship between the development of atherosclerotic plaque formation and the amount of pro-inflammatory (M1) activated macrophages in situ. Methods: The authors studied the ability of circulating monocytes isolated from patients with diabetes (n = 28), coronary heart disease (CHD) (n = 27) and healthy subjects (n = 50) to be activated into M1 phenotype in vitro. Results: Increased levels of basal and... Read more
    Published on: 14 Nov 2017  | Viewed:73  | Downloaded:10
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  • Review|Open Access

    An overview of different methods of myocardial protection currently employed peri-transplantation

    Sanjeet Singh Avtaar Singh , Sudeep Das De , Cristiano Spadaccio , Colin Berry , Nawwar Al-Attar
    Myocardial protection is integral to the functioning of hearts in day to day cardiac surgery. However, due to the longer ischaemic times, it becomes pivotal in the management of organs during transplantation. There are many different strategies employed to ensure diligent and judicious myocardial protection during donor management, transportation of the heart and the post-operative period. Given the limited supply of organs and the increasing waiting lists for heart transplants worldwide, it has become an area of renewed interest with many innovations and inventions using the principles of... Read more
    Published on: 26 Oct 2017  | Viewed:166  | Downloaded:3
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    Relationship between peculiarities of atrial fibrillation, body mass index and adipokines levels

    Oleksandr Bilovol , Yuliya Shaposhnikova , Iryna Ilchenko , Anna Shalimova
    Aim: To assess the value of body mass index (BMI) and adipokine levels in predicting development of atrial fibrillation (AF) in the general population. Methods: Three hundred and ninety eight patients were examined for the presence of phenotype metabolically healthy obesity (MHO), according to the Wildman criteria; adipokine levels were assessed by enzyme immunoassay method; AF was assessed by electrocardiography (ECG) and/or by ECG diurnal monitoring. Results: Obesity (group 1) and overweight (group 2) was present in 23.7% and 42.0% of participants; while 21.1% were normal body weight... Read more
    Published on: 25 Oct 2017  | Viewed:143  | Downloaded:6
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    New markers of atherosclerosis: a threshold level of heteroplasmy in mtDNA mutations

    Margarita A. Sazonova , Anastasia I. Ryzhkova , Vasily V. Sinyov , Elena V. Galitsyna , Varvara A. Orekhova , Alexandra A. Melnichenko , Alexander N. Orekhov , Alessio L. Ravani , Igor A. Sobenin
    Aim: The aim of the present article was the detection of threshold heteroplasmy level of mitochondrial DNA mutations, above which a patient is at increased risk of atherosclerotic lesions. Besides, this parameter was detected for mutations, in which after reaching threshold heteroplasmy level, a protective antiatherogenic effect started to appear. Methods: The participants of the study were 700 women and men from the Moscow region. Fragments of DNA, amplified by polymerase chain reaction, were analyzed with pyrosequencing technology. Then on the basis of pyrograms’ peaks in the samples, the... Read more
    Published on: 19 Oct 2017  | Viewed:435  | Downloaded:18
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    Is insulin pro-atherogenic at the cellular level?

    Igor A. Sobenin , Varvara A. Orekhova , Andrey V. Grechko , Alexander N. Orekhov
    Aim: This study was undertaken to test the hypothesis that insulin treatment has unexpected pro-atherogenic effects at the cellular level, namely, proliferative activity and intracellular cholesterol content. Methods: Primary cultures of subendothelial cells derived from non-atherosclerotic human aorta and mouse peritoneal macrophages were used to investigate the in vitro effect of insulin on atherosclerosis-related parameters, such as cellular cholesterol content and proliferation rate. Additionally, the effect of insulin treatment in 33 type 1 diabetic patients on serum atherogenicity... Read more
    Published on: 17 Oct 2017  | Viewed:74  | Downloaded:6
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  • Case Report|Open Access

    Sternal malunion fixation using a Titanium Sternal Fixation System in a diabetic patient. The first of its kind in Scotland

    Sanjeet Singh Avtaar Singh , Massimo Capoccia , Kamal Deep , Nawwar Al-Attar
    Sternal non-union is a rare but serious complication post-sternotomy. It is defined as sternal pain with clicking, instability, or both for more than 6 months in the absence of infection and usually presents in an outpatient setting. It may result in multiple admissions to the hospital for surgical debridement and wound care therapies. Several risk factors have been identified in the literature but treatment options are limited. Proven benefits of increased stability and decreased incidence of non-union using the principles of rigid fixation have been described in other surgical specialties... Read more
    Published on: 28 Sep 2017  | Viewed:277  | Downloaded:9
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Vessel Plus Online ISSN: 2574-1209
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