Online First
  • Review

    Probable protective role of diabetes mellitus in takotsubo cardiomyopathy: a review

    Shreyas Gowdar , Samridhi Syal , Lovely Chhabra
    Takotsubo cardiomyopathy (TC) is a syndrome that predominantly affects postmenopausal women and is characterized by transient regional systolic dysfunction of the left ventricle which occurs in the absence of angiographic evidence of significant obstructive coronary artery disease. It is often but not always triggered by emotional or physical stressful stimuli. In most cases, the regional ventricular dysfunction extends beyond a single epicardial coronary artery territory. It typically involves the apex, with rare atypical presentations involving the base and right ventricle. Although the...
    First Published on: 17 Aug 2017
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  • Short Communication

    Potential use of buccal epithelium for genetic diagnosis of atherosclerosis using mtDNA mutations

    Vasily V. Sinyov , Margarita A. Sazonova , Anastasia I. Ryzhkova , Elena V. Galitsyna , Alexsandra A. Melnichenko , Anton Y. Postnov , Alexander N. Orekhov , Andrey V. Grechko , Igor A. Sobenin
    Aim: The aim of this pilot study was to compare the heteroplasmy levels of specific mitochondrial (mt)DNA mutations in human buccal epithelial and whole blood cells in participants with different degrees of predisposition to atherosclerosis. The potential for buccal epithelium to be used for the genetic diagnosis of atherosclerosis using mtDNA mutations was assessed. Methods: Samples of buccal epithelial and whole blood cells were obtained from 134 donors. DNA was extracted from the samples and subjected to polymerase chain reaction and pyrosequencing. The threshold heteroplasmy levels of...
    First Published on: 20 Jul 2017
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  • Review

    Omega-3 polyunsaturated fatty acids and cardiovascular health: a molecular view into structure and function

    María José Calvo , María Sofía Martínez , Wheeler Torres , Mervin Chávez-Castillo , Eliana Luzardo , Nelson Villasmil , Juan Salazar , Manuel Velasco , Valmore Bermúdez
    Given the notorious impact of cardiovascular disease (CVD) as the current leading cause of mortality worldwide, the prevention, identification and management of CV risk factors represents a priority in daily clinical practice. Several studies have shown the beneficial effects of dietary omega-3 polyunsaturated fatty acids (PUFAs) on CV health. Their derivatives, eicosapentaenoic acid and docosahexaenoic acid, intervene in multiple metabolic pathways, including: regulation of the inflammatory response, by reducing the synthesis of pro-inflammatory cytokines; regulation of platelet...
    First Published on: 17 Jul 2017
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  • Case Report

    Stab wound with transection of left vertebral artery at V3

    Robert Bertellotti , Oluwaseye Ayoola Ogun , Angel Mironov , Juan Antonio Asensio
    While vertebral artery injuries are uncommon, they can have significant morbidity if not identified and treated in a timely fashion. While the majority of vertebral artery injuries are the result of blunt injury and typically have favorable outcomes, a substantial percentage of patients with penetrating injury to the neck may also have vertebral artery injury necessitating angiographic or operative intervention. A 45-year-old male sustained a single stab wound to the apex of the posterior triangle of the neck, below the left mastoid process. At the scene, Emergency Medical Services...
    First Published on: 11 Jul 2017
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  • Original Article

    Perivascular mast cells promote neointimal elastin deposition and suppress chronic vein graft restenosis in hyperlipidaemic mice

    Junxi Wu , Catherine Lawrence , Roger M. Wadsworth , Simon Kennedy
    Aim: Mast cells are versatile innate immune cells and are reported to promote vascular inflammation and neointimal lesion formation, thereby contributing to the development of vascular stenosis and atherosclerosis. However, it is not clear whether mast cells also regulate vascular matrix remodelling in established neointima. This study addressed the hypothesis that perivascular mast cells regulate neointimal matrix remodelling using a mouse vein graft model. Methods: The impact of mast cells on neointimal remodelling was investigated using mast cell-deficient animals in both normolipidaemic...
    First Published on: 11 Jul 2017
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  • Case Report

    Leriche’s syndrome: a rare complication following anterior approach lumbar spinal surgery

    Ramyashree Tummala , Keyvan Ravakhah , Anjan Gupta
    Leriche’s syndrome is an aortic occlusive disease, which is due to obliteration of distal aorta above the site of bifurcation of common iliac arteries. The classic triad of symptoms include claudication, impotence, and absent or decreased femoral pulses. It may be acute or chronic in onset. Most of the cases are chronic in nature due to baseline pathophysiology involving atherosclerotic changes in the aorta. There are many causes of acute leriche’s syndrome like surgical manipulation, trauma, thromboembolic disease, hypercoagulability, atrial fibrillation, neoplasm, intraplaque hemorrhage...
    First Published on: 11 Apr 2017
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