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  • Original Article|Open Access

    Small dense and desialylated low density lipoprotein in diabetic patients

    Igor A. Sobenin , Elena V. Galitsyna , Andrey V. Grechko , Alexander N. Orekhov
    Aim: This study was undertaken to investigate the physicochemical properties of modified low density lipoprotein (LDL) in diabetes. Methods: LDL from 10 type 1 and 10 type 2 diabetic patients, as well as LDL from 10 non-diabetic subjects, was subdivided into bound and non-bound fractions by affinity chromatography on Ricinus communis agglutinin-agarose, and further characterized by sialic acid content, hydrated density, electrophoretic mobility, and the ability to induce cholesterol deposition in cultured cells. Results: The non-bound LDL fraction was similar to native LDL from healthy...
    Published on: 31 Mar 2017
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  • Original Article|Open Access

    Crimping and deployment of metallic and polymeric stents -- finite element modelling

    Alessandro Schiavone , Tian-Yang Qiu , Li-Guo Zhao
    Aim: This paper aims to compare the mechanical performance of metallic (Xience) and bioresorbable polymeric (Elixir) stents during the process of crimping and deployment. Methods: Finite element software ABAQUS was used to create the geometrical models and meshes for the balloon, stent and diseased artery. To simulate the crimping of stents, 12 rigid plates were generated around the stent and subjected to radially enforced displacement. The deployment of both stents was simulated by applying internal pressure to the balloon, where hard contacts were defined between balloon, stent and...
    Published on: 31 Mar 2017
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  • Editorial|Open Access

    Myocardial ischemia in women: problems and challenges

    Tamar Vakhtangadze , Nino Gakhokidze
    Published on: 27 Jun 2017
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  • Review|Open Access

    Mimetic peptide of ubiquitin-interacting motif of epsin as a cancer therapeutic-perspective in brain tumor therapy through regulating VEGFR2 signaling

    Yunzhou Dong , Hao Wu , Jerry Dong , Kai Song , Habibunnabi Ashiqur Rahman , Rheal Towner , Hong Chen
    Epsins, endocytic adaptor proteins required for internalization of ubiquitylated receptors, are generally upregulated in human cancers. It has been characterized that mice deficient of epsins in the endothelium inhibit tumor growth by dysregulating vascular endothelial growth factor receptor-2 (VEGFR2) signaling and non-productive tumor angiogenesis. Binding of the epsin ubiquitin (Ub)-interacting motif (UIM) with ubiquitylated VEGFR2 is a critical mechanism for epsin-dependent VEGFR2 endocytosis and degradation, indicative of epsin UIM as a potential therapeutic target. A Computer Assisted...
    Published on: 31 Mar 2017
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  • Short Communication|Open Access

    Homocysteine and D-dimer levels and multilayer computed tomography for diagnosing pulmonary artery thromboembolism

    Fridon Todua , Manana Akhvlediani , Elena Vorobiova , Giorgi Tsivtsivadze , Anna Baramidze
    Aim: D-dimer reportedly plays a leading role in diagnosing pulmonary embolism. Additionally, homocysteine is an established risk factor for atherosclerosis, vascular disease, and thrombosis. Herein, the authors aimed to evaluate the diagnostic significance of D-dimer and homocysteine levels, together with multi-detector computed tomography (CT) in suspected pulmonary embolism. Methods: The authors examined patients suffering from conditions and complaints that are typical of pulmonary artery thromboembolism (PATE), such as chest pain, haemoptysis, dyspnoea, tachycardia, arterial...
    Published on: 31 Mar 2017
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  • Short Communication|Open Access

    Heart and vascular remodeling in essential hypertension and type 2 diabetes is dependent on genetic polymorphisms

    Anna Shalimova
    Aim: To study heart and vascular remodeling in essential hypertension (EH) and concomitant type 2 diabetes mellitus (DM2) with respect to genetic polymorphism of the angiotensin II receptor type 1 (AGTR1) gene and peroxisome proliferator-activated receptor-γ2 (PPARγ2). Methods: Biochemical blood analysis, echocardiographic evaluation of mitral diastolic blood flow and tissue Doppler spectral modes, reactive hyperemia, color Doppler mapping. Results: Patients with A/C and C/C genotypes of the AGTR1 gene had higher blood pressure, more pronounced metabolic disorders, a larger left ventricle...
    Published on: 27 Jun 2017
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  • Editorial|Open Access

    A foreword from the Editor-in-Chief

    Aaron S. Dumont
    Published on: 31 Mar 2017
    [HTML]   [PDF]   Viewed:676 Downloaded:42
  • Review|Open Access

    Blood purification in intensive care patients with multiple organ dysfunction syndrome and sepsis after cardiac surgery

    Michael Yaroustovsky , Marina Abramyan , Ekaterina Komardina , Helen Nazarova
    Extracorporeal blood purification is becoming increasingly important in intensive therapy for multiple organ dysfunction syndrome (MODS) and sepsis, considering all of their pathophysiological aspects. The results of treatment, particularly in children, considering their anatomical and physiological features, are related to the severity and progression of organ failure, the indications that are found, the choice of method, and the timely initiation of blood purification. Multiple organ support therapy is the aim of introducing and applying blood purification today. Various extracorporeal...
    Published on: 27 Jun 2017
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  • Original Article|Open Access

    The effect of postoperative malperfusion after surgical treatment of type A acute aortic dissection on early and mid-term survival

    Paolo Nardi , Carlo Olevano , Carlo Bassano , Emanuele Bovio , Lorenzo Cecchetti , Stefano Forlani , Giovanni Ruvolo
    Aim: To evaluate whether postoperative malperfusion (PM) affected in-hospital and long-term survival in acute type A aortic dissection (AAAD) surgical patients and to identify risk factors for PM. Methods: Patients who underwent AAAD surgery at a single institution between January 2005 and March 2015 were retrospectively analyzed. Results: Two-hundred fourteen patients with complete data were identified. At presentation, 119 patients (55.6%) showed preoperative malperfusions: 68 (31.8%) were cerebral, 38 (17.7%) were renal, and 13 (6.1%) were mesenteric. PM was found in 55 patients (25.7%)....
    Published on: 27 Jun 2017
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  • Original Article|Open Access

    Initial experience with bioresorbable vascular scaffolds for percutaneous revascularisation in patients with acute coronary syndrome

    Alberto Cordero , Ramón López-Palop , Pilar Carrillo , Araceli Frutos , Clara Gunturiz , Maria García-Carrilero , Vicente Bertomeu-Martinez
    Aim: Bioresorbable vascular scaffolds (BVS) have recently been introduced to minimise the long-term complications of metallic stents in acute coronary syndrome (ACS), but their benefits have not been well analysed. Methods: The authors studied all ACS patients treated with any kind of stent at a single centre between March 2013 (when the first BVS was implanted) and June 2016. Results: The study included 951 subjects, mean age 67.9 ± 13.3 years, mean Global Registry of Acute Coronary Events (GRACE) score 148.5 ± 44.8, 75.2% men and 38.2% with an ST-segment elevation myocardial infarction....
    Published on: 27 Jun 2017
    [HTML]   [PDF]   Viewed:461 Downloaded:32
  • Case Report|Open Access

    LDL apheresis or PCSK9 inhibition? Sometimes we have to combine them

    Mariann Harangi , Lilla Juhász , Bíborka Nádró , József Balla , György Paragh
    This study presents the case of a female patient with severe heterozygous familial hypercholesterolemia. Despite the combined maximum dose oral treatment with rosuvastatin and ezetimibe, we found markedly elevated lipid parameters. Therefore, we indicated monthly selective low density lipoprotein (LDL) apheresis treatment using the Direct Adsorption of Lipoproteins system. After more than 2 years the lipid levels of the patients were still above the therapeutic goals. Finally, we completed the treatment by the inhibitor evolocumab biweekly. Further LDL cholesterol (LDL-C) reduction was...
    Published on: 27 Jun 2017
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  • Original Article|Open Access

    Predictors of hormonal and metabolic disorders of arterial hypertension and type 2 diabetes mellitus comorbidity

    Oleksandr Bilovol
    Aim: These experiments studied adipokine and interleukin imbalances during the development and progression of metabolic disorders in patients with arterial hypertension (AH) and type 2 diabetes mellitus (T2DM). Methods: Ninety-five patients with stage II second degree AH (53 males and 42 females, mean age 54.7 ± 5.4 years) were observed. The cohort was separated into: group 1 (n = 48) patients with AH and group 2 (n = 47) patients with both AH and T2DM. Serum protein levels of omentin, adiponectin, tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), resistin, interleukin (IL)-1β,...
    Published on: 31 Mar 2017
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  • Original Article|Open Access

    Galectin-3 as a potential biomarker of metabolic disorders and cardiovascular remodeling in patients with hypertension and type 2 diabetes

    Lesya Bobronnikova
    Aim: To determine the impact of galectin-3 levels on the progression of metabolic disorders and structural-functional changes in the myocardium and blood vessels in patients with concomitant systemic arterial hypertension (AH) and type 2 diabetes mellitus (type 2 DM). Methods: Ninety-five patients with hypertension stage II grade 2 (53 males and 42 females) were examined. The patients were separated: group 1 (n = 32) patients with AH, without carbohydrate metabolism disorders; group 2 (n = 30) patients with AH and pre-diabetes; group 3 (n = 33) concomitant AH and type 2 DM. Carbohydrate...
    Published on: 27 Jun 2017
    [HTML]   [PDF]   Viewed:195 Downloaded:12
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