Most Viewed: Last TWO YEARS
  • Original Article|Open Access

    Small dense and desialylated low density lipoprotein in diabetic patients

    Igor A. Sobenin , Elena V. Galitsyna , Andrey V. Grechko , Alexander N. Orekhov
    Aim: This study was undertaken to investigate the physicochemical properties of modified low density lipoprotein (LDL) in diabetes. Methods: LDL from 10 type 1 and 10 type 2 diabetic patients, as well as LDL from 10 non-diabetic subjects, was subdivided into bound and non-bound fractions by affinity chromatography on Ricinus communis agglutinin-agarose, and further characterized by sialic acid content, hydrated density, electrophoretic mobility, and the ability to induce cholesterol deposition in cultured cells. Results: The non-bound LDL fraction was similar to native LDL from healthy... Read more
    Vessel Plus 2017;1:29-37. | doi:10.20517/2574-1209.2016.12
    Published on: 31 Mar 2017  | Viewed:57939  | Downloaded:140
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  • Original Article|Open Access

    Crimping and deployment of metallic and polymeric stents -- finite element modelling

    Alessandro Schiavone , Tian-Yang Qiu , Li-Guo Zhao
    Aim: This paper aims to compare the mechanical performance of metallic (Xience) and bioresorbable polymeric (Elixir) stents during the process of crimping and deployment. Methods: Finite element software ABAQUS was used to create the geometrical models and meshes for the balloon, stent and diseased artery. To simulate the crimping of stents, 12 rigid plates were generated around the stent and subjected to radially enforced displacement. The deployment of both stents was simulated by applying internal pressure to the balloon, where hard contacts were defined between balloon, stent and... Read more
    Vessel Plus 2017;1:12-21. | doi:10.20517/2574-1209.2016.03
    Published on: 31 Mar 2017  | Viewed:4150  | Downloaded:387
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  • Review|Open Access

    Omega-3 polyunsaturated fatty acids and cardiovascular health: a molecular view into structure and function

    María José Calvo , María Sofía Martínez , Wheeler Torres , Mervin Chávez-Castillo , Eliana Luzardo , Nelson Villasmil , Juan Salazar , Manuel Velasco , Valmore Bermúdez
    Given the notorious impact of cardiovascular disease (CVD) as the current leading cause of mortality worldwide, the prevention, identification and management of CV risk factors represents a priority in daily clinical practice. Several studies have shown the beneficial effects of dietary omega-3 polyunsaturated fatty acids (PUFAs) on CV health. Their derivatives, eicosapentaenoic acid and docosahexaenoic acid, intervene in multiple metabolic pathways, including: regulation of the inflammatory response, by reducing the synthesis of pro-inflammatory cytokines; regulation of platelet... Read more
    Vessel Plus 2017;1:116-28. | doi:10.20517/2574-1209.2017.14
    Published on: 26 Sep 2017  | Viewed:3368  | Downloaded:109
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  • Review|Open Access

    Mimetic peptide of ubiquitin-interacting motif of epsin as a cancer therapeutic-perspective in brain tumor therapy through regulating VEGFR2 signaling

    Yunzhou Dong , Hao Wu , Jerry Dong , Kai Song , Habibunnabi Ashiqur Rahman , Rheal Towner , Hong Chen
    Epsins, endocytic adaptor proteins required for internalization of ubiquitylated receptors, are generally upregulated in human cancers. It has been characterized that mice deficient of epsins in the endothelium inhibit tumor growth by dysregulating vascular endothelial growth factor receptor-2 (VEGFR2) signaling and non-productive tumor angiogenesis. Binding of the epsin ubiquitin (Ub)-interacting motif (UIM) with ubiquitylated VEGFR2 is a critical mechanism for epsin-dependent VEGFR2 endocytosis and degradation, indicative of epsin UIM as a potential therapeutic target. A Computer Assisted... Read more
    Vessel Plus 2017;1:3-11. | doi:10.20517/2574-1209.2016.01
    Published on: 31 Mar 2017  | Viewed:2338  | Downloaded:137
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  • Editorial|Open Access

    Myocardial ischemia in women: problems and challenges

    Tamar Vakhtangadze , Nino Gakhokidze
    Vessel Plus 2017;1:43-8. | doi:10.20517/2574-1209.2016.05
    Published on: 27 Jun 2017  | Viewed:2215  | Downloaded:93
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  • Review|Open Access

    Blood purification in intensive care patients with multiple organ dysfunction syndrome and sepsis after cardiac surgery

    Michael Yaroustovsky , Marina Abramyan , Ekaterina Komardina , Helen Nazarova
    Extracorporeal blood purification is becoming increasingly important in intensive therapy for multiple organ dysfunction syndrome (MODS) and sepsis, considering all of their pathophysiological aspects. The results of treatment, particularly in children, considering their anatomical and physiological features, are related to the severity and progression of organ failure, the indications that are found, the choice of method, and the timely initiation of blood purification. Multiple organ support therapy is the aim of introducing and applying blood purification today. Various extracorporeal... Read more
    Vessel Plus 2017;1:49-60. | doi:10.20517/2574-1209.2017.11
    Published on: 27 Jun 2017  | Viewed:1715  | Downloaded:102
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  • Short Communication|Open Access

    Heart and vascular remodeling in essential hypertension and type 2 diabetes is dependent on genetic polymorphisms

    Anna Shalimova
    Aim: To study heart and vascular remodeling in essential hypertension (EH) and concomitant type 2 diabetes mellitus (DM2) with respect to genetic polymorphism of the angiotensin II receptor type 1 (AGTR1) gene and peroxisome proliferator-activated receptor-γ2 (PPARγ2). Methods: Biochemical blood analysis, echocardiographic evaluation of mitral diastolic blood flow and tissue Doppler spectral modes, reactive hyperemia, color Doppler mapping. Results: Patients with A/C and C/C genotypes of the AGTR1 gene had higher blood pressure, more pronounced metabolic disorders, a larger left ventricle... Read more
    Vessel Plus 2017;1:84-90. | doi:10.20517/2574-1209.2016.08
    Published on: 27 Jun 2017  | Viewed:1684  | Downloaded:53
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  • Short Communication|Open Access

    Homocysteine and D-dimer levels and multilayer computed tomography for diagnosing pulmonary artery thromboembolism

    Fridon Todua , Manana Akhvlediani , Elena Vorobiova , Giorgi Tsivtsivadze , Anna Baramidze
    Aim: D-dimer reportedly plays a leading role in diagnosing pulmonary embolism. Additionally, homocysteine is an established risk factor for atherosclerosis, vascular disease, and thrombosis. Herein, the authors aimed to evaluate the diagnostic significance of D-dimer and homocysteine levels, together with multi-detector computed tomography (CT) in suspected pulmonary embolism. Methods: The authors examined patients suffering from conditions and complaints that are typical of pulmonary artery thromboembolism (PATE), such as chest pain, haemoptysis, dyspnoea, tachycardia, arterial... Read more
    Vessel Plus 2017;1:38-42. | doi:10.20517/2574-1209.2016.06
    Published on: 31 Mar 2017  | Viewed:1266  | Downloaded:51
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  • Case Report|Open Access

    LDL apheresis or PCSK9 inhibition? Sometimes we have to combine them

    Mariann Harangi , Lilla Juhász , Bíborka Nádró , József Balla , György Paragh
    This study presents the case of a female patient with severe heterozygous familial hypercholesterolemia. Despite the combined maximum dose oral treatment with rosuvastatin and ezetimibe, we found markedly elevated lipid parameters. Therefore, we indicated monthly selective low density lipoprotein (LDL) apheresis treatment using the Direct Adsorption of Lipoproteins system. After more than 2 years the lipid levels of the patients were still above the therapeutic goals. Finally, we completed the treatment by the inhibitor evolocumab biweekly. Further LDL cholesterol (LDL-C) reduction was... Read more
    Vessel Plus 2017;1:91-5. | doi:10.20517/2574-1209.2017.08
    Published on: 27 Jun 2017  | Viewed:1181  | Downloaded:102
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  • Original Article|Open Access

    The effect of postoperative malperfusion after surgical treatment of type A acute aortic dissection on early and mid-term survival

    Paolo Nardi , Carlo Olevano , Carlo Bassano , Emanuele Bovio , Lorenzo Cecchetti , Stefano Forlani , Giovanni Ruvolo
    Aim: To evaluate whether postoperative malperfusion (PM) affected in-hospital and long-term survival in acute type A aortic dissection (AAAD) surgical patients and to identify risk factors for PM. Methods: Patients who underwent AAAD surgery at a single institution between January 2005 and March 2015 were retrospectively analyzed. Results: Two-hundred fourteen patients with complete data were identified. At presentation, 119 patients (55.6%) showed preoperative malperfusions: 68 (31.8%) were cerebral, 38 (17.7%) were renal, and 13 (6.1%) were mesenteric. PM was found in 55 patients (25.7%).... Read more
    Vessel Plus 2017;1:77-83. | doi:10.20517/2574-1209.2017.07
    Published on: 27 Jun 2017  | Viewed:1135  | Downloaded:78
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  • Case Report|Open Access

    Leriche’s syndrome: a rare complication following anterior approach lumbar spinal surgery

    Ramyashree Tummala , Keyvan Ravakhah , Anjan Gupta
    Leriche’s syndrome is an aortic occlusive disease, which is due to obliteration of distal aorta above the site of bifurcation of common iliac arteries. The classic triad of symptoms include claudication, impotence, and absent or decreased femoral pulses. It may be acute or chronic in onset. Most of the cases are chronic in nature due to baseline pathophysiology involving atherosclerotic changes in the aorta. There are many causes of acute leriche’s syndrome like surgical manipulation, trauma, thromboembolic disease, hypercoagulability, atrial fibrillation, neoplasm, intraplaque hemorrhage... Read more
    Vessel Plus 2017;1:155-8. | doi:10.20517/2574-1209.2016.14
    Published on: 26 Sep 2017  | Viewed:1050  | Downloaded:139
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  • Editorial|Open Access

    A foreword from the Editor-in-Chief

    Aaron S. Dumont
    Vessel Plus 2017;1:1-2. | doi:10.20517/2574-1209.2017.03
    Published on: 31 Mar 2017  | Viewed:999  | Downloaded:57
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  • Case Report|Open Access

    Stab wound with transection of left vertebral artery at V3

    Robert Bertellotti , Oluwaseye Ayoola Ogun , Angel Mironov , Juan Antonio Asensio
    While vertebral artery injuries are uncommon, they can have significant morbidity if not identified and treated in a timely fashion. While the majority of vertebral artery injuries are the result of blunt injury and typically have favorable outcomes, a substantial percentage of patients with penetrating injury to the neck may also have vertebral artery injury necessitating angiographic or operative intervention. A 45-year-old male sustained a single stab wound to the apex of the posterior triangle of the neck, below the left mastoid process. At the scene, Emergency Medical Services... Read more
    Vessel Plus 2017;1:159-62. | doi:10.20517/2574-1209.2017.10
    Published on: 26 Sep 2017  | Viewed:997  | Downloaded:30
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  • Review|Open Access

    Energetic metabolism in cardiomyocytes: molecular basis of heart ischemia and arrhythmogenesis

    María Sofía Martínez , Andrés García , Eliana Luzardo , Mervin Chávez-Castillo , Luis Carlos Olivar , Juan Salazar , Manuel Velasco , Joselyn Joanna Rojas Quintero , Valmore Bermúdez
    Cardiac muscle contraction is a strictly regulated process which conjugates a series of electrophysiological, biochemical and mechanic events, resulting in the pumping of blood to all bodily tissues. These phenomena require a very high energetic demand both for generating the necessary mechanical force, and for maintaining cellular homeostasis during the process. In the myocardium, fatty acids (FA) represent the main energy substrate, although other secondary substrates, such as glucose and ketone bodies, may also be used. Nevertheless, under certain conditions such as heart failure or... Read more
    Vessel Plus 2017;1:230-41. | doi:10.20517/2574-1209.2017.34
    Published on: 28 Dec 2017  | Viewed:965  | Downloaded:66
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  • Original Article|Open Access

    Initial experience with bioresorbable vascular scaffolds for percutaneous revascularisation in patients with acute coronary syndrome

    Alberto Cordero , Ramón López-Palop , Pilar Carrillo , Araceli Frutos , Clara Gunturiz , Maria García-Carrilero , Vicente Bertomeu-Martinez
    Aim: Bioresorbable vascular scaffolds (BVS) have recently been introduced to minimise the long-term complications of metallic stents in acute coronary syndrome (ACS), but their benefits have not been well analysed. Methods: The authors studied all ACS patients treated with any kind of stent at a single centre between March 2013 (when the first BVS was implanted) and June 2016. Results: The study included 951 subjects, mean age 67.9 ± 13.3 years, mean Global Registry of Acute Coronary Events (GRACE) score 148.5 ± 44.8, 75.2% men and 38.2% with an ST-segment elevation myocardial infarction.... Read more
    Vessel Plus 2017;1:68-76. | doi:10.20517/2574-1209.2017.02
    Published on: 27 Jun 2017  | Viewed:799  | Downloaded:46
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    New markers of atherosclerosis: a threshold level of heteroplasmy in mtDNA mutations

    Margarita A. Sazonova , Anastasia I. Ryzhkova , Vasily V. Sinyov , Elena V. Galitsyna , Varvara A. Orekhova , Alexandra A. Melnichenko , Alexander N. Orekhov , Alessio L. Ravani , Igor A. Sobenin
    Aim: The aim of the present article was the detection of threshold heteroplasmy level of mitochondrial DNA mutations, above which a patient is at increased risk of atherosclerotic lesions. Besides, this parameter was detected for mutations, in which after reaching threshold heteroplasmy level, a protective antiatherogenic effect started to appear. Methods: The participants of the study were 700 women and men from the Moscow region. Fragments of DNA, amplified by polymerase chain reaction, were analyzed with pyrosequencing technology. Then on the basis of pyrograms’ peaks in the samples, the... Read more
    Vessel Plus 2017;1:182-91. | doi:10.20517/2574-1209.2017.16
    Published on: 28 Dec 2017  | Viewed:761  | Downloaded:30
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  • Case Report|Open Access

    Sternal malunion fixation using a Titanium Sternal Fixation System in a diabetic patient. The first of its kind in Scotland

    Sanjeet Singh Avtaar Singh , Massimo Capoccia , Kamal Deep , Nawwar Al-Attar
    Sternal non-union is a rare but serious complication post-sternotomy. It is defined as sternal pain with clicking, instability, or both for more than 6 months in the absence of infection and usually presents in an outpatient setting. It may result in multiple admissions to the hospital for surgical debridement and wound care therapies. Several risk factors have been identified in the literature but treatment options are limited. Proven benefits of increased stability and decreased incidence of non-union using the principles of rigid fixation have been described in other surgical specialties... Read more
    Vessel Plus 2017;1:242-5. | doi:10.20517/2574-1209.2017.25
    Published on: 28 Dec 2017  | Viewed:740  | Downloaded:15
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  • Original Article|Open Access

    Predictors of hormonal and metabolic disorders of arterial hypertension and type 2 diabetes mellitus comorbidity

    Oleksandr Bilovol
    Aim: These experiments studied adipokine and interleukin imbalances during the development and progression of metabolic disorders in patients with arterial hypertension (AH) and type 2 diabetes mellitus (T2DM). Methods: Ninety-five patients with stage II second degree AH (53 males and 42 females, mean age 54.7 ± 5.4 years) were observed. The cohort was separated into: group 1 (n = 48) patients with AH and group 2 (n = 47) patients with both AH and T2DM. Serum protein levels of omentin, adiponectin, tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), resistin, interleukin (IL)-1β,... Read more
    Vessel Plus 2017;1:22-8. | doi:10.20517/2574-1209.2016.11
    Published on: 31 Mar 2017  | Viewed:689  | Downloaded:38
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  • Original Article|Open Access

    Perivascular mast cells promote neointimal elastin deposition and suppress chronic vein graft restenosis in hyperlipidaemic mice

    Junxi Wu , Catherine Lawrence , Roger M. Wadsworth , Simon Kennedy
    Aim: Mast cells are versatile innate immune cells and are reported to promote vascular inflammation and neointimal lesion formation, thereby contributing to the development of vascular stenosis and atherosclerosis. However, it is not clear whether mast cells also regulate vascular matrix remodelling in established neointima. This study addressed the hypothesis that perivascular mast cells regulate neointimal matrix remodelling using a mouse vein graft model. Methods: The impact of mast cells on neointimal remodelling was investigated using mast cell-deficient animals in both normolipidaemic... Read more
    Vessel Plus 2017;1:137-44. | doi:10.20517/2574-1209.2017.15
    Published on: 26 Sep 2017  | Viewed:632  | Downloaded:43
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    Chemical composition of circulating native and desialylated low density lipoprotein: what is the difference?

    Vladimir I. Alipov , Vasily N. Sukhorukov , Vasily P. Karagodin , Andrey V. Grechko , Alexander N. Orekhov
    Atherosclerosis and related cardiovascular disorders remain the leading global cause of morbidity and mortality. Modified low density lipoprotein (LDL) is considered to play a crucial role in atherosclerosis development. During the past decades, several types of atherogenic LDL modification have been discovered. Desialylation was one of the atherogenic modifications observed in circulating atherogenic LDL in vivo. Sialic acid level negatively correlates with triglyceride and cholesterol contents. Desialylated LDL is small, dense and highly susceptible to oxidation, as reported for... Read more
    Vessel Plus 2017;1:107-15. | doi:10.20517/2574-1209.2017.20
    Published on: 26 Sep 2017  | Viewed:596  | Downloaded:42
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  • Review|Open Access

    An overview of different methods of myocardial protection currently employed peri-transplantation

    Sanjeet Singh Avtaar Singh , Sudeep Das De , Cristiano Spadaccio , Colin Berry , Nawwar Al-Attar
    Myocardial protection is integral to the functioning of hearts in day to day cardiac surgery. However, due to the longer ischaemic times, it becomes pivotal in the management of organs during transplantation. There are many different strategies employed to ensure diligent and judicious myocardial protection during donor management, transportation of the heart and the post-operative period. Given the limited supply of organs and the increasing waiting lists for heart transplants worldwide, it has become an area of renewed interest with many innovations and inventions using the principles of... Read more
    Vessel Plus 2017;1:213-29. | doi:10.20517/2574-1209.2017.26
    Published on: 28 Dec 2017  | Viewed:568  | Downloaded:30
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    Associations of lifestyle and dietary habits with hyperlipidemia in Lebanon

    Ali A. Samaha , Fouad Zouein , Maya Gebbawi , Mirna Fawaz , Raheel Houjayri , Rana Samaha , Safaa Baydoun , Ali H. Eid
    Aim: This study was designed to evaluate the effects of dietary and lifestyle habits on several blood lipid parameters in the Lebanese population. Methods: This was a cross-sectional study for 2,000 individuals, of whom 1,003 completed the survey about their dietary and lifestyle habits. Anthropometric measurements and blood tests were performed and recorded. Results: Up to 53.2% of the population was hypercholesterolemic. Gender and age contributed to the prevalence of high levels of low density lipoprotein cholesterol (LDL-C) or triglycerides. Prevalence of hypercholesterolemia,... Read more
    Vessel Plus 2017;1:98-106. | doi:10.20517/2574-1209.2017.18
    Published on: 26 Sep 2017  | Viewed:555  | Downloaded:42
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  • Review|Open Access

    Probable protective role of diabetes mellitus in takotsubo cardiomyopathy: a review

    Shreyas Gowdar , Samridhi Syal , Lovely Chhabra
    Takotsubo cardiomyopathy (TC) is a syndrome that predominantly affects postmenopausal women and is characterized by transient regional systolic dysfunction of the left ventricle which occurs in the absence of angiographic evidence of significant obstructive coronary artery disease. It is often but not always triggered by emotional or physical stressful stimuli. In most cases, the regional ventricular dysfunction extends beyond a single epicardial coronary artery territory. It typically involves the apex, with rare atypical presentations involving the base and right ventricle. Although the... Read more
    Vessel Plus 2017;1:129-36. | doi:10.20517/2574-1209.2017.12
    Published on: 26 Sep 2017  | Viewed:535  | Downloaded:32
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  • Short Communication|Open Access

    Potential use of buccal epithelium for genetic diagnosis of atherosclerosis using mtDNA mutations

    Vasily V. Sinyov , Margarita A. Sazonova , Anastasia I. Ryzhkova , Elena V. Galitsyna , Alexsandra A. Melnichenko , Anton Y. Postnov , Alexander N. Orekhov , Andrey V. Grechko , Igor A. Sobenin
    Aim: The aim of this pilot study was to compare the heteroplasmy levels of specific mitochondrial (mt)DNA mutations in human buccal epithelial and whole blood cells in participants with different degrees of predisposition to atherosclerosis. The potential for buccal epithelium to be used for the genetic diagnosis of atherosclerosis using mtDNA mutations was assessed. Methods: Samples of buccal epithelial and whole blood cells were obtained from 134 donors. DNA was extracted from the samples and subjected to polymerase chain reaction and pyrosequencing. The threshold heteroplasmy levels of... Read more
    Vessel Plus 2017;1:145-50. | doi:10.20517/2574-1209.2016.04
    Published on: 26 Sep 2017  | Viewed:528  | Downloaded:34
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    Relationship between peculiarities of atrial fibrillation, body mass index and adipokines levels

    Oleksandr Bilovol , Yuliya Shaposhnikova , Iryna Ilchenko , Anna Shalimova
    Aim: To assess the value of body mass index (BMI) and adipokine levels in predicting development of atrial fibrillation (AF) in the general population. Methods: Three hundred and ninety eight patients were examined for the presence of phenotype metabolically healthy obesity (MHO), according to the Wildman criteria; adipokine levels were assessed by enzyme immunoassay method; AF was assessed by electrocardiography (ECG) and/or by ECG diurnal monitoring. Results: Obesity (group 1) and overweight (group 2) was present in 23.7% and 42.0% of participants; while 21.1% were normal body weight... Read more
    Vessel Plus 2017;1:196-201. | doi:10.20517/2574-1209.2017.17
    Published on: 28 Dec 2017  | Viewed:515  | Downloaded:22
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  • Case Report|Open Access

    Bjork-Shiley tricuspid valve endocarditis thirty years after implantation

    Kasra Shaikhrezai , Sanjeet Singh Avtaar Singh , Cristiano Spadaccio , Steven Hunter
    The Bjork-Shiley valve has been in use since 1971. Its longevity has been well reported in the literature. The study report a case of the Bjork-Shiley valve implanted in a young man, who presents with bacterial endocarditis 30 years after implantation of the valve. Transthoracic echocardiography showed vegetations in the mechanical tricuspid valve, with positive blood cultures csonfirming the diagnosis. Artificial valves increase the risk of contracting endocarditis but this is the first report of a case of bacterial endocarditis occurring in a mechanical tricuspid valve replacement 30... Read more
    Vessel Plus 2017;1:151-4. | doi:10.20517/2574-1209.2017.06
    Published on: 26 Sep 2017  | Viewed:515  | Downloaded:25
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  • Original Article|Open Access

    Galectin-3 as a potential biomarker of metabolic disorders and cardiovascular remodeling in patients with hypertension and type 2 diabetes

    Lesya Bobronnikova
    Aim: To determine the impact of galectin-3 levels on the progression of metabolic disorders and structural-functional changes in the myocardium and blood vessels in patients with concomitant systemic arterial hypertension (AH) and type 2 diabetes mellitus (type 2 DM). Methods: Ninety-five patients with hypertension stage II grade 2 (53 males and 42 females) were examined. The patients were separated: group 1 (n = 32) patients with AH, without carbohydrate metabolism disorders; group 2 (n = 30) patients with AH and pre-diabetes; group 3 (n = 33) concomitant AH and type 2 DM. Carbohydrate... Read more
    Vessel Plus 2017;1:61-7. | doi:10.20517/2574-1209.2016.10
    Published on: 27 Jun 2017  | Viewed:509  | Downloaded:30
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  • Review|Open Access

    Adipose tissue-derived cytokines, CTRPs as biomarkers and therapeutic targets in metabolism and the cardiovascular system

    Ya-Jing Wang , Jian-Li Zhao , Wayne Bond Lau , Jing Liu , Rui Guo , Xin-Liang Ma
    Increasing evidence indicates that adipose tissue-originated cytokines mediate communication between obesity-related exogenous molecules and the molecular events that initiate the metabolic syndrome and the inflammatory responses in the cardiovascular system (CVS). Adipose tissue-derived cytokines including the C1q/tumor necrosis factor-related proteins (CTRPs), a 15-member family of novel adipokines, has attracted much interest due to its metabolic regulatory and anti-inflammatory effect and appear to play a pathophysiological role in metabolism and immunity. To date, 15 members of CTRP... Read more
    Vessel Plus 2017;1:202-12. | doi:10.20517/2574-1209.2017.29
    Published on: 28 Dec 2017  | Viewed:448  | Downloaded:24
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    Proinflammatory monocyte polarization in type 2 diabetes mellitus and coronary heart disease

    Nikita G. Nikiforov , Karina O. Galstyan , Liudmila V. Nedosugova , Natalia V. Elizova , Kira I. Kolmychkova , Ekaterina A. Ivanova
    Aim: Type 2 diabetes mellitus (T2DM) is associated with rapid progression of atherosclerosis. There is no doubt that inflammation is involved in atherogenesis. Recent studies showed the relationship between the development of atherosclerotic plaque formation and the amount of pro-inflammatory (M1) activated macrophages in situ. Methods: The authors studied the ability of circulating monocytes isolated from patients with diabetes (n = 28), coronary heart disease (CHD) (n = 27) and healthy subjects (n = 50) to be activated into M1 phenotype in vitro. Results: Increased levels of basal and... Read more
    Vessel Plus 2017;1:192-5. | doi:10.20517/2574-1209.2017.21
    Published on: 28 Dec 2017  | Viewed:375  | Downloaded:24
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    HDL subfraction distribution and HDL function in untreated dyslipidemic patients

    Mariann Harangi , Anita Szentpéteri , Bíborka Nádró , Hajnalka Lőrincz , Ildikó Seres , Dénes Páll , György Paragh
    Aim: The protective role of high-density lipoprotein (HDL) against atherosclerosis is well known. However, both structural and functional changes of the HDL particles may affect its protective efficacy. Increased levels of HDL-associated myeloperoxidase (MPO) and decreased HDL-linked paraoxonase-1 (PON1) activity have been reported in dyslipidemic patients. Some changes in HDL subfraction distributions were also studied previously, but data on structural and functional changes in dyslipidemia are not complete. Therefore, the authors aimed to evaluate these qualitative and quantitative... Read more
    Vessel Plus 2017;1:166-73. | doi:10.20517/2574-1209.2017.27
    Published on: 28 Dec 2017  | Viewed:370  | Downloaded:23
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  • Review|Open Access

    Traumatic pulmonary artery injury: a review of the recent literature

    Youichi Yanagawa , Kouhei Ishikawa , Hiroki Nagasawa , Ikuto Takeuchi , Kei Jitsuiki , Hiromichi Ohsaka , Kazuhiko Omori
    Pulmonary artery injury (PAI) is rare, lethal clinical entity. Traumatic PAI is anatomically classified into transection/rupture/laceration, pseudoaneurysm, dissection and fistula. In addition, traumatic PAI is clinically classified into two major categories: iatrogenic and non-iatrogenic, depending on the mechanism of the trauma. The frequency, clinical symptoms and treatment differ between the two clinical categories. If PAI can be managed appropriately and promptly in patients without cardiac arrest, the patient may be saved, as PAI can be easily controlled with appropriate procedures... Read more
    Vessel Plus 2018;2:1. | doi:10.20517/2574-1209.2017.37
    Published on: 26 Jan 2018  | Viewed:357  | Downloaded:24
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    Is insulin pro-atherogenic at the cellular level?

    Igor A. Sobenin , Varvara A. Orekhova , Andrey V. Grechko , Alexander N. Orekhov
    Aim: This study was undertaken to test the hypothesis that insulin treatment has unexpected pro-atherogenic effects at the cellular level, namely, proliferative activity and intracellular cholesterol content. Methods: Primary cultures of subendothelial cells derived from non-atherosclerotic human aorta and mouse peritoneal macrophages were used to investigate the in vitro effect of insulin on atherosclerosis-related parameters, such as cellular cholesterol content and proliferation rate. Additionally, the effect of insulin treatment in 33 type 1 diabetic patients on serum atherogenicity... Read more
    Vessel Plus 2017;1:174-81. | doi:10.20517/2574-1209.2017.19
    Published on: 28 Dec 2017  | Viewed:350  | Downloaded:19
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    A prominent role of D-dimer in inflammation and atherosclerosis

    Veronika A. Myasoedova , Paolo Poggio , Alessandro Parolari
    Vessel Plus 2017;1:96-7. | doi:10.20517/2574-1209.2017.22
    Published on: 26 Sep 2017  | Viewed:298  | Downloaded:32
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  • Case Report|Open Access

    Temporizing amplatzer closure of an aorto-enteric fistula associated with a blind aortic stump via a translumbar approach

    S. Keisin Wang , Justin R. King , Ashley R. Gutwein , Raghu L. Motaganahalli , Andres Fajardo , Gary W. Lemmon
    We present a case of an aorto-enteric fistula (AEF) with chronic, persistent bleeding from a blind aortic stump managed by endovascular means. This novel approach may have extended the life of a patient who would otherwise have been subject to a high perioperative morbidity or persistent bleeding and death. While our patient ultimately expired, we believe this technique can be considered for temporization in highly-selected patients. Read more
    Vessel Plus 2018;2:3. | doi:10.20517/2574-1209.2017.38
    Published on: 7 Feb 2018  | Viewed:265  | Downloaded:15
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  • Review|Open Access

    Surgical revascularization for acute coronary syndromes: a narrative review

    Joseph H. Joo , Joshua M. Liao , Faisal G. Bakaeen , Danny Chu
    Acute coronary syndrome (ACS) comprises a spectrum of disease that includes unstable angina, non-ST-elevation myocardial infarction, and ST-elevation myocardial infarction. Clinical management of patients with ACS has greatly evolved over the last two decades, but ACS remains an important cause of morbidity and mortality in patients with coronary artery disease. This narrative review describes the indication, timing, and approaches to surgical revascularization in the context of ACS. In particular, the review discusses and compares the utilization of off-pump coronary artery bypass grafting... Read more
    Vessel Plus 2018;2:2. | doi:10.20517/2574-1209.2017.36
    Published on: 2 Feb 2018  | Viewed:209  | Downloaded:17
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    Introduction of the special issue “Atherosclerosis and Related Diseases”

    Alexander N. Orekhov , Ekaterina A. Ivanova
    Vessel Plus 2017;1:163-5. | doi:10.20517/2574-1209.2017.33
    Published on: 28 Dec 2017  | Viewed:180  | Downloaded:13
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Vessel Plus Online ISSN: 2574-1209
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