Most Viewed: Last ONE YEAR
  • Original Article|Open Access

    Small dense and desialylated low density lipoprotein in diabetic patients

    Igor A. Sobenin , Elena V. Galitsyna , Andrey V. Grechko , Alexander N. Orekhov
    Aim: This study was undertaken to investigate the physicochemical properties of modified low density lipoprotein (LDL) in diabetes. Methods: LDL from 10 type 1 and 10 type 2 diabetic patients, as well as LDL from 10 non-diabetic subjects, was subdivided into bound and non-bound fractions by affinity chromatography on Ricinus communis agglutinin-agarose, and further characterized by sialic acid content, hydrated density, electrophoretic mobility, and the ability to induce cholesterol deposition in cultured cells. Results: The non-bound LDL fraction was similar to native LDL from healthy... Read more
    Vessel Plus 2017;1:29-37. | doi:10.20517/2574-1209.2016.12
    Published on: 31 Mar 2017  | Viewed:51382  | Downloaded:108
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  • Original Article|Open Access

    Crimping and deployment of metallic and polymeric stents -- finite element modelling

    Alessandro Schiavone , Tian-Yang Qiu , Li-Guo Zhao
    Aim: This paper aims to compare the mechanical performance of metallic (Xience) and bioresorbable polymeric (Elixir) stents during the process of crimping and deployment. Methods: Finite element software ABAQUS was used to create the geometrical models and meshes for the balloon, stent and diseased artery. To simulate the crimping of stents, 12 rigid plates were generated around the stent and subjected to radially enforced displacement. The deployment of both stents was simulated by applying internal pressure to the balloon, where hard contacts were defined between balloon, stent and... Read more
    Vessel Plus 2017;1:12-21. | doi:10.20517/2574-1209.2016.03
    Published on: 31 Mar 2017  | Viewed:2735  | Downloaded:332
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  • Editorial|Open Access

    Myocardial ischemia in women: problems and challenges

    Tamar Vakhtangadze , Nino Gakhokidze
    Vessel Plus 2017;1:43-8. | doi:10.20517/2574-1209.2016.05
    Published on: 27 Jun 2017  | Viewed:1848  | Downloaded:78
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  • Review|Open Access

    Mimetic peptide of ubiquitin-interacting motif of epsin as a cancer therapeutic-perspective in brain tumor therapy through regulating VEGFR2 signaling

    Yunzhou Dong , Hao Wu , Jerry Dong , Kai Song , Habibunnabi Ashiqur Rahman , Rheal Towner , Hong Chen
    Epsins, endocytic adaptor proteins required for internalization of ubiquitylated receptors, are generally upregulated in human cancers. It has been characterized that mice deficient of epsins in the endothelium inhibit tumor growth by dysregulating vascular endothelial growth factor receptor-2 (VEGFR2) signaling and non-productive tumor angiogenesis. Binding of the epsin ubiquitin (Ub)-interacting motif (UIM) with ubiquitylated VEGFR2 is a critical mechanism for epsin-dependent VEGFR2 endocytosis and degradation, indicative of epsin UIM as a potential therapeutic target. A Computer Assisted... Read more
    Vessel Plus 2017;1:3-11. | doi:10.20517/2574-1209.2016.01
    Published on: 31 Mar 2017  | Viewed:1633  | Downloaded:112
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  • Review|Open Access

    Omega-3 polyunsaturated fatty acids and cardiovascular health: a molecular view into structure and function

    María José Calvo , María Sofía Martínez , Wheeler Torres , Mervin Chávez-Castillo , Eliana Luzardo , Nelson Villasmil , Juan Salazar , Manuel Velasco , Valmore Bermúdez
    Given the notorious impact of cardiovascular disease (CVD) as the current leading cause of mortality worldwide, the prevention, identification and management of CV risk factors represents a priority in daily clinical practice. Several studies have shown the beneficial effects of dietary omega-3 polyunsaturated fatty acids (PUFAs) on CV health. Their derivatives, eicosapentaenoic acid and docosahexaenoic acid, intervene in multiple metabolic pathways, including: regulation of the inflammatory response, by reducing the synthesis of pro-inflammatory cytokines; regulation of platelet... Read more
    Vessel Plus 2017;1:116-28. | doi:10.20517/2574-1209.2017.14
    Published on: 26 Sep 2017  | Viewed:1418  | Downloaded:76
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  • Short Communication|Open Access

    Heart and vascular remodeling in essential hypertension and type 2 diabetes is dependent on genetic polymorphisms

    Anna Shalimova
    Aim: To study heart and vascular remodeling in essential hypertension (EH) and concomitant type 2 diabetes mellitus (DM2) with respect to genetic polymorphism of the angiotensin II receptor type 1 (AGTR1) gene and peroxisome proliferator-activated receptor-γ2 (PPARγ2). Methods: Biochemical blood analysis, echocardiographic evaluation of mitral diastolic blood flow and tissue Doppler spectral modes, reactive hyperemia, color Doppler mapping. Results: Patients with A/C and C/C genotypes of the AGTR1 gene had higher blood pressure, more pronounced metabolic disorders, a larger left ventricle... Read more
    Vessel Plus 2017;1:84-90. | doi:10.20517/2574-1209.2016.08
    Published on: 27 Jun 2017  | Viewed:1220  | Downloaded:39
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  • Review|Open Access

    Blood purification in intensive care patients with multiple organ dysfunction syndrome and sepsis after cardiac surgery

    Michael Yaroustovsky , Marina Abramyan , Ekaterina Komardina , Helen Nazarova
    Extracorporeal blood purification is becoming increasingly important in intensive therapy for multiple organ dysfunction syndrome (MODS) and sepsis, considering all of their pathophysiological aspects. The results of treatment, particularly in children, considering their anatomical and physiological features, are related to the severity and progression of organ failure, the indications that are found, the choice of method, and the timely initiation of blood purification. Multiple organ support therapy is the aim of introducing and applying blood purification today. Various extracorporeal... Read more
    Vessel Plus 2017;1:49-60. | doi:10.20517/2574-1209.2017.11
    Published on: 27 Jun 2017  | Viewed:960  | Downloaded:79
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  • Short Communication|Open Access

    Homocysteine and D-dimer levels and multilayer computed tomography for diagnosing pulmonary artery thromboembolism

    Fridon Todua , Manana Akhvlediani , Elena Vorobiova , Giorgi Tsivtsivadze , Anna Baramidze
    Aim: D-dimer reportedly plays a leading role in diagnosing pulmonary embolism. Additionally, homocysteine is an established risk factor for atherosclerosis, vascular disease, and thrombosis. Herein, the authors aimed to evaluate the diagnostic significance of D-dimer and homocysteine levels, together with multi-detector computed tomography (CT) in suspected pulmonary embolism. Methods: The authors examined patients suffering from conditions and complaints that are typical of pulmonary artery thromboembolism (PATE), such as chest pain, haemoptysis, dyspnoea, tachycardia, arterial... Read more
    Vessel Plus 2017;1:38-42. | doi:10.20517/2574-1209.2016.06
    Published on: 31 Mar 2017  | Viewed:893  | Downloaded:39
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  • Editorial|Open Access

    A foreword from the Editor-in-Chief

    Aaron S. Dumont
    Vessel Plus 2017;1:1-2. | doi:10.20517/2574-1209.2017.03
    Published on: 31 Mar 2017  | Viewed:805  | Downloaded:46
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  • Original Article|Open Access

    The effect of postoperative malperfusion after surgical treatment of type A acute aortic dissection on early and mid-term survival

    Paolo Nardi , Carlo Olevano , Carlo Bassano , Emanuele Bovio , Lorenzo Cecchetti , Stefano Forlani , Giovanni Ruvolo
    Aim: To evaluate whether postoperative malperfusion (PM) affected in-hospital and long-term survival in acute type A aortic dissection (AAAD) surgical patients and to identify risk factors for PM. Methods: Patients who underwent AAAD surgery at a single institution between January 2005 and March 2015 were retrospectively analyzed. Results: Two-hundred fourteen patients with complete data were identified. At presentation, 119 patients (55.6%) showed preoperative malperfusions: 68 (31.8%) were cerebral, 38 (17.7%) were renal, and 13 (6.1%) were mesenteric. PM was found in 55 patients (25.7%).... Read more
    Vessel Plus 2017;1:77-83. | doi:10.20517/2574-1209.2017.07
    Published on: 27 Jun 2017  | Viewed:697  | Downloaded:67
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  • Case Report|Open Access

    LDL apheresis or PCSK9 inhibition? Sometimes we have to combine them

    Mariann Harangi , Lilla Juhász , Bíborka Nádró , József Balla , György Paragh
    This study presents the case of a female patient with severe heterozygous familial hypercholesterolemia. Despite the combined maximum dose oral treatment with rosuvastatin and ezetimibe, we found markedly elevated lipid parameters. Therefore, we indicated monthly selective low density lipoprotein (LDL) apheresis treatment using the Direct Adsorption of Lipoproteins system. After more than 2 years the lipid levels of the patients were still above the therapeutic goals. Finally, we completed the treatment by the inhibitor evolocumab biweekly. Further LDL cholesterol (LDL-C) reduction was... Read more
    Vessel Plus 2017;1:91-5. | doi:10.20517/2574-1209.2017.08
    Published on: 27 Jun 2017  | Viewed:676  | Downloaded:84
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  • Original Article|Open Access

    Initial experience with bioresorbable vascular scaffolds for percutaneous revascularisation in patients with acute coronary syndrome

    Alberto Cordero , Ramón López-Palop , Pilar Carrillo , Araceli Frutos , Clara Gunturiz , Maria García-Carrilero , Vicente Bertomeu-Martinez
    Aim: Bioresorbable vascular scaffolds (BVS) have recently been introduced to minimise the long-term complications of metallic stents in acute coronary syndrome (ACS), but their benefits have not been well analysed. Methods: The authors studied all ACS patients treated with any kind of stent at a single centre between March 2013 (when the first BVS was implanted) and June 2016. Results: The study included 951 subjects, mean age 67.9 ± 13.3 years, mean Global Registry of Acute Coronary Events (GRACE) score 148.5 ± 44.8, 75.2% men and 38.2% with an ST-segment elevation myocardial infarction.... Read more
    Vessel Plus 2017;1:68-76. | doi:10.20517/2574-1209.2017.02
    Published on: 27 Jun 2017  | Viewed:648  | Downloaded:34
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  • Case Report|Open Access

    Leriche’s syndrome: a rare complication following anterior approach lumbar spinal surgery

    Ramyashree Tummala , Keyvan Ravakhah , Anjan Gupta
    Leriche’s syndrome is an aortic occlusive disease, which is due to obliteration of distal aorta above the site of bifurcation of common iliac arteries. The classic triad of symptoms include claudication, impotence, and absent or decreased femoral pulses. It may be acute or chronic in onset. Most of the cases are chronic in nature due to baseline pathophysiology involving atherosclerotic changes in the aorta. There are many causes of acute leriche’s syndrome like surgical manipulation, trauma, thromboembolic disease, hypercoagulability, atrial fibrillation, neoplasm, intraplaque hemorrhage... Read more
    Vessel Plus 2017;1:155-8. | doi:10.20517/2574-1209.2016.14
    Published on: 26 Sep 2017  | Viewed:603  | Downloaded:112
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  • Original Article|Open Access

    Predictors of hormonal and metabolic disorders of arterial hypertension and type 2 diabetes mellitus comorbidity

    Oleksandr Bilovol
    Aim: These experiments studied adipokine and interleukin imbalances during the development and progression of metabolic disorders in patients with arterial hypertension (AH) and type 2 diabetes mellitus (T2DM). Methods: Ninety-five patients with stage II second degree AH (53 males and 42 females, mean age 54.7 ± 5.4 years) were observed. The cohort was separated into: group 1 (n = 48) patients with AH and group 2 (n = 47) patients with both AH and T2DM. Serum protein levels of omentin, adiponectin, tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), resistin, interleukin (IL)-1β,... Read more
    Vessel Plus 2017;1:22-8. | doi:10.20517/2574-1209.2016.11
    Published on: 31 Mar 2017  | Viewed:513  | Downloaded:28
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  • Original Article|Open Access

    Perivascular mast cells promote neointimal elastin deposition and suppress chronic vein graft restenosis in hyperlipidaemic mice

    Junxi Wu , Catherine Lawrence , Roger M. Wadsworth , Simon Kennedy
    Aim: Mast cells are versatile innate immune cells and are reported to promote vascular inflammation and neointimal lesion formation, thereby contributing to the development of vascular stenosis and atherosclerosis. However, it is not clear whether mast cells also regulate vascular matrix remodelling in established neointima. This study addressed the hypothesis that perivascular mast cells regulate neointimal matrix remodelling using a mouse vein graft model. Methods: The impact of mast cells on neointimal remodelling was investigated using mast cell-deficient animals in both normolipidaemic... Read more
    Vessel Plus 2017;1:137-44. | doi:10.20517/2574-1209.2017.15
    Published on: 26 Sep 2017  | Viewed:386  | Downloaded:30
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  • Original Article|Open Access

    Galectin-3 as a potential biomarker of metabolic disorders and cardiovascular remodeling in patients with hypertension and type 2 diabetes

    Lesya Bobronnikova
    Aim: To determine the impact of galectin-3 levels on the progression of metabolic disorders and structural-functional changes in the myocardium and blood vessels in patients with concomitant systemic arterial hypertension (AH) and type 2 diabetes mellitus (type 2 DM). Methods: Ninety-five patients with hypertension stage II grade 2 (53 males and 42 females) were examined. The patients were separated: group 1 (n = 32) patients with AH, without carbohydrate metabolism disorders; group 2 (n = 30) patients with AH and pre-diabetes; group 3 (n = 33) concomitant AH and type 2 DM. Carbohydrate... Read more
    Vessel Plus 2017;1:61-7. | doi:10.20517/2574-1209.2016.10
    Published on: 27 Jun 2017  | Viewed:330  | Downloaded:18
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  • Case Report|Open Access

    Stab wound with transection of left vertebral artery at V3

    Robert Bertellotti , Oluwaseye Ayoola Ogun , Angel Mironov , Juan Antonio Asensio
    While vertebral artery injuries are uncommon, they can have significant morbidity if not identified and treated in a timely fashion. While the majority of vertebral artery injuries are the result of blunt injury and typically have favorable outcomes, a substantial percentage of patients with penetrating injury to the neck may also have vertebral artery injury necessitating angiographic or operative intervention. A 45-year-old male sustained a single stab wound to the apex of the posterior triangle of the neck, below the left mastoid process. At the scene, Emergency Medical Services... Read more
    Vessel Plus 2017;1:159-62. | doi:10.20517/2574-1209.2017.10
    Published on: 26 Sep 2017  | Viewed:326  | Downloaded:13
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    Associations of lifestyle and dietary habits with hyperlipidemia in Lebanon

    Ali A. Samaha , Fouad Zouein , Maya Gebbawi , Mirna Fawaz , Raheel Houjayri , Rana Samaha , Safaa Baydoun , Ali H. Eid
    Aim: This study was designed to evaluate the effects of dietary and lifestyle habits on several blood lipid parameters in the Lebanese population. Methods: This was a cross-sectional study for 2,000 individuals, of whom 1,003 completed the survey about their dietary and lifestyle habits. Anthropometric measurements and blood tests were performed and recorded. Results: Up to 53.2% of the population was hypercholesterolemic. Gender and age contributed to the prevalence of high levels of low density lipoprotein cholesterol (LDL-C) or triglycerides. Prevalence of hypercholesterolemia,... Read more
    Vessel Plus 2017;1:98-106. | doi:10.20517/2574-1209.2017.18
    Published on: 26 Sep 2017  | Viewed:236  | Downloaded:19
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    Chemical composition of circulating native and desialylated low density lipoprotein: what is the difference?

    Vladimir I. Alipov , Vasily N. Sukhorukov , Vasily P. Karagodin , Andrey V. Grechko , Alexander N. Orekhov
    Atherosclerosis and related cardiovascular disorders remain the leading global cause of morbidity and mortality. Modified low density lipoprotein (LDL) is considered to play a crucial role in atherosclerosis development. During the past decades, several types of atherogenic LDL modification have been discovered. Desialylation was one of the atherogenic modifications observed in circulating atherogenic LDL in vivo. Sialic acid level negatively correlates with triglyceride and cholesterol contents. Desialylated LDL is small, dense and highly susceptible to oxidation, as reported for... Read more
    Vessel Plus 2017;1:107-15. | doi:10.20517/2574-1209.2017.20
    Published on: 26 Sep 2017  | Viewed:231  | Downloaded:19
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  • Short Communication|Open Access

    Potential use of buccal epithelium for genetic diagnosis of atherosclerosis using mtDNA mutations

    Vasily V. Sinyov , Margarita A. Sazonova , Anastasia I. Ryzhkova , Elena V. Galitsyna , Alexsandra A. Melnichenko , Anton Y. Postnov , Alexander N. Orekhov , Andrey V. Grechko , Igor A. Sobenin
    Aim: The aim of this pilot study was to compare the heteroplasmy levels of specific mitochondrial (mt)DNA mutations in human buccal epithelial and whole blood cells in participants with different degrees of predisposition to atherosclerosis. The potential for buccal epithelium to be used for the genetic diagnosis of atherosclerosis using mtDNA mutations was assessed. Methods: Samples of buccal epithelial and whole blood cells were obtained from 134 donors. DNA was extracted from the samples and subjected to polymerase chain reaction and pyrosequencing. The threshold heteroplasmy levels of... Read more
    Vessel Plus 2017;1:145-50. | doi:10.20517/2574-1209.2016.04
    Published on: 26 Sep 2017  | Viewed:187  | Downloaded:14
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Vessel Plus Online ISSN: 2574-1209
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