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  • Original Article

    Small dense and desialylated low density lipoprotein in diabetic patients

    Igor A. Sobenin , Elena V. Galitsyna , Andrey V. Grechko , Alexander N. Orekhov
    Aim: This study was undertaken to investigate the physicochemical properties of modified low density lipoprotein (LDL) in diabetes. Methods: LDL from 10 type 1 and 10 type 2 diabetic patients, as well as LDL from 10 non-diabetic subjects, was subdivided into bound and non-bound fractions by affinity chromatography on Ricinus communis agglutinin-agarose, and further characterized by sialic acid content, hydrated density, electrophoretic mobility, and the ability to induce cholesterol deposition in cultured cells. Results: The non-bound LDL fraction was similar to native LDL from healthy...
    Published on: 31 Mar 2017
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  • Original Article

    Predictors of hormonal and metabolic disorders of arterial hypertension and type 2 diabetes mellitus comorbidity

    Oleksandr Bilovol
    Aim: These experiments studied adipokine and interleukin imbalances during the development and progression of metabolic disorders in patients with arterial hypertension (AH) and type 2 diabetes mellitus (T2DM). Methods: Ninety-five patients with stage II second degree AH (53 males and 42 females, mean age 54.7 ± 5.4 years) were observed. The cohort was separated into: group 1 (n = 48) patients with AH and group 2 (n = 47) patients with both AH and T2DM. Serum protein levels of omentin, adiponectin, tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), resistin, interleukin (IL)-1β,...
    Published on: 31 Mar 2017
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  • Review

    Mimetic peptide of ubiquitin-interacting motif of epsin as a cancer therapeutic-perspective in brain tumor therapy through regulating VEGFR2 signaling

    Yunzhou Dong , Hao Wu , Jerry Dong , Kai Song , Habibunnabi Ashiqur Rahman , Rheal Towner , Hong Chen
    Epsins, endocytic adaptor proteins required for internalization of ubiquitylated receptors, are generally upregulated in human cancers. It has been characterized that mice deficient of epsins in the endothelium inhibit tumor growth by dysregulating vascular endothelial growth factor receptor-2 (VEGFR2) signaling and non-productive tumor angiogenesis. Binding of the epsin ubiquitin (Ub)-interacting motif (UIM) with ubiquitylated VEGFR2 is a critical mechanism for epsin-dependent VEGFR2 endocytosis and degradation, indicative of epsin UIM as a potential therapeutic target. A Computer Assisted...
    Published on: 31 Mar 2017
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  • Short Communication

    Homocysteine and D-dimer levels and multilayer computed tomography for diagnosing pulmonary artery thromboembolism

    Fridon Todua , Manana Akhvlediani , Elena Vorobiova , Giorgi Tsivtsivadze , Anna Baramidze
    Aim: D-dimer reportedly plays a leading role in diagnosing pulmonary embolism. Additionally, homocysteine is an established risk factor for atherosclerosis, vascular disease, and thrombosis. Herein, the authors aimed to evaluate the diagnostic significance of D-dimer and homocysteine levels, together with multi-detector computed tomography (CT) in suspected pulmonary embolism. Methods: The authors examined patients suffering from conditions and complaints that are typical of pulmonary artery thromboembolism (PATE), such as chest pain, haemoptysis, dyspnoea, tachycardia, arterial...
    Published on: 31 Mar 2017
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  • Original Article

    Crimping and deployment of metallic and polymeric stents -- finite element modelling

    Alessandro Schiavone , Tian-Yang Qiu , Li-Guo Zhao
    Aim: This paper aims to compare the mechanical performance of metallic (Xience) and bioresorbable polymeric (Elixir) stents during the process of crimping and deployment. Methods: Finite element software ABAQUS was used to create the geometrical models and meshes for the balloon, stent and diseased artery. To simulate the crimping of stents, 12 rigid plates were generated around the stent and subjected to radially enforced displacement. The deployment of both stents was simulated by applying internal pressure to the balloon, where hard contacts were defined between balloon, stent and...
    Published on: 31 Mar 2017
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  • Editorial

    A foreword from the Editor-in-Chief

    Aaron S. Dumont
    Published on: 31 Mar 2017
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