Latest
  • Correction|Open Access

    Correction: Energetic metabolism in cardiomyocytes: molecular basis of heart ischemia and arrhythmogenesis

    María Sofía Martínez, Andrés García, Eliana Luzardo, Mervin Chávez-Castillo, Luis Carlos Olivar, Juan Salazar, Manuel Velasco, Joselyn Joanna Rojas Quintero, Valmore Bermúdez
    Vessel Plus 2018;2:32. | doi:10.20517/2574-1209.2018.68
    Published on: 23 Oct 2018  | Viewed:0  | Downloaded:0
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  • Meeting Abstracts|Open Access

    Selected meeting abstracts of 2018 healthcare and cardiology conference

    Ahmed Ahmed Fouad Abdelwahab Ahmed
    Vessel Plus 2018;2:31. | doi:10.20517/2574-1209.2018.58
    Published on: 16 Oct 2018  | Viewed:155  | Downloaded:4
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  • Review|Open Access

    Thrombospondins and remodeling of the tumor microenvironment

    Olga Stenina-Adognravi, Santoshi Muppala, Jasmine Gajeton
    Vascular remodeling defines cancer growth and aggressiveness. Although cancer cells produce pro-angiogenic signals, the fate of angiogenesis critically depends on the cancer microenvironment. Composition of the extracellular matrix (ECM) and tumor inflammation determine whether a cancer will remain dormant, will be recognized by the immune system and eliminated, or whether the tumor will develop and lead to the spread and metastasis of cancer cells. Thrombospondins (TSPs), a family of ECM proteins that has long been associated with the regulation of angiogenesis and cancer, regulate... Read more
    This article belongs to the Special Issue Vascular Remodeling 2018: the Updates
    Vessel Plus 2018;2:30. | doi:10.20517/2574-1209.2018.40
    Published on: 10 Oct 2018  | Viewed:147  | Downloaded:4
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  • Review|Open Access

    A current view of G protein-coupled receptor - mediated signaling in pulmonary hypertension: finding opportunities for therapeutic intervention

    Derek Strassheim, Vijaya Karoor, Kurt Stenmark, Alexander Verin, Evgenia Gerasimovskaya
    Pathological vascular remodeling is observed in various cardiovascular diseases including pulmonary hypertension (PH), a disease of unknown etiology that has been characterized by pulmonary artery vasoconstriction, right ventricular hypertrophy, vascular inflammation, and abnormal angiogenesis in pulmonary circulation. G protein-coupled receptors (GPCRs) are the largest family in the genome and widely expressed in cardiovascular system. They regulate all aspects of PH pathophysiology and represent therapeutic targets. We overview GPCRs function in vasoconstriction, vasodilation, vascular... Read more
    This article belongs to the Special Issue Vascular Remodeling 2018: the Updates
    Vessel Plus 2018;2:29. | doi:10.20517/2574-1209.2018.44
    Published on: 30 Sep 2018  | Viewed:427  | Downloaded:29
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  • Review|Open Access

    Transcatheter aortic valve replacement: is anesthesiologic management linked to surgical outcomes?

    Chiara Candela, Annalaura Di Pumpo, Alessandro Centonze, Fabrizio Cucciniello, Domenico Sarubbi, Felice Eugenio Agrò
    Aortic valve replacement (AVR) is the current standard treatment for severe aortic stenosis, nonetheless, many patients are not suitable to AVR because of high risk related to advanced age, impaired cardiac function, or comorbidities. Given these considerations, transcatheter aortic valve replacement or implantation (TAVR or TAVI) has emerged in the last decade as an alternative to surgery and has become the treatment of choice for severe aortic stenosis in patients with prohibitive surgical risk. In the context of this kind of hybrid procedure, the anesthesiologist plays a central role... Read more
    This article belongs to the Special Issue State of the Art in Cardiovascular Surgery
    Vessel Plus 2018;2:28. | doi:10.20517/2574-1209.2018.31
    Published on: 29 Sep 2018  | Viewed:137  | Downloaded:4
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  • Original Article|Open Access

    Age-associated features of oxidative stress as marker of vascular aging in comorbid course of hypertension and type 2 diabetes mellitus

    Valeriya Nemtsova, Olexander Bilovol, Irina Ilchenko, Anna Shalimova
    Aim: To evaluate activity of oxidative stress (OS) as marker of vascular aging in different age groups of patients with combined course of arterial hypertension (HT) and type 2 diabetes mellitus (T2DM). Methods: 126 patients (average age 57.8 ± 6.2 years) with stage II HT and compensated T2DM were divided into 2 subgroups: 2a (n = 59) - aged 45-60 years; 2b (n = 97) - aged 61-75 years; 30 patients with isolated stage II HT (comparison group), 20 practically healthy individuals (control group). The activity of antioxidative [glutathione peroxidase, sulfhydryl groups (SH-groups)] and... Read more
    This article belongs to the Special Issue Atherosclerosis, Diabetes Mellitus, and Metabolic Syndrome: Commonalities and Differences in Phenotypes, Metabolic Pathways and Genetics
    Vessel Plus 2018;2:27. | doi:10.20517/2574-1209.2018.48
    Published on: 28 Sep 2018  | Viewed:145  | Downloaded:8
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  • Review|Open Access

    Complications of transcatheter aortic valve replacement and rescue attempts

    Burak Can Depboylu, Serkan Yazman, Bugra Harmandar
    As a novel treatment modality, transcatheter aortic valve replacement (TAVR) is widely used for patients with severe aortic valve stenosis who have high surgical risk worldwide. However, this promising alternative procedure has different types of complication risks including, cerebrovascular events, vascular complications, bleeding, coronary obstruction, myocardial infarction, valve regurgitation, valve malpositioning or migration, conduction disturbances and acute kidney injury which may occur during and/or after the procedure. These complications may be seen up to one third of the... Read more
    This article belongs to the Special Issue State of the Art in Cardiovascular Surgery
    Vessel Plus 2018;2:26. | doi:10.20517/2574-1209.2018.39
    Published on: 21 Sep 2018  | Viewed:198  | Downloaded:11
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  • Review|Open Access

    Fetal programming and its effects on vascular pulmonary circulation

    Carmela Rita Balistreri
    Into the scientific community, consensus about the emerging concept of “the fetal origin of adult diseases” is growing. It sustains that the parental (of the two parents) adversities, and the related external influences, during the intra-utero/perinatal life of each eutherian mammal organism, human included, can permanently set the structure and functionality of specific body systems (i.e., immune, endocrine, nervous and cardiovascular systems), predisposing them to early ageing and disease during adulthood. The pulmonary circulation system also appears to be one of its targets. Established... Read more
    This article belongs to the Special Issue Vascular Remodeling 2018: the Updates
    Vessel Plus 2018;2:25. | doi:10.20517/2574-1209.2018.35
    Published on: 19 Sep 2018  | Viewed:196  | Downloaded:8
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  • Review|Open Access

    Vascular approaches and its potential implications in transcatheter aortic valve implantation

    Alessandro Sticchi, Edoardo Bressi, Annunziata Nusca, Germano Di Sciascio
    Transcatheter aortic valve implantation (TAVI) has become in the last years a primary therapeutic tool in order to treat percutaneously severe aortic stenosis in frail patients with multiple comorbidity and a high surgical risk. In almost all cases, the complexity of patients who are candidates for TAVI is also reflected in challenging access sites. This vascular issue addresses the invasive play of constantly evolving devices and resulting complications have a considerable impact on patient morbidity and mortality. For this reason, the study and the choice of the different access site... Read more
    This article belongs to the Special Issue State of the Art in Cardiovascular Surgery
    Vessel Plus 2018;2:23. | doi:10.20517/2574-1209.2018.47
    Published on: 13 Sep 2018  | Viewed:266  | Downloaded:10
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  • Review|Open Access

    The endothelial progenitor cell dysfunction in hypertension: the diagnostic and predictive values

    Alexander E Berezin
    Hypertension remains a leading risk factor of cardiovascular (CV) events and disease in the general population. The prevalence of hypertension is present in developed and developing countries and according to various assessments may fluctuate between 30% to 90% with considerable regional differences. Hypertension influences CV risk and mortality rate through target organ damages that affect vasculature particularly endothelium. Endothelial dysfunction is an independent risk factor of CV complications. Recent studies have shown that a decreased number and altered function of circulating... Read more
    Vessel Plus 2018;2:22. | doi:10.20517/2574-1209.2018.23
    Published on: 13 Sep 2018  | Viewed:247  | Downloaded:15
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  • Original Article|Open Access

    Is tacrolimus more likely to induce diabetes mellitus than ciclosporin in heart transplant patients?

    Anisha Jagpal, Sudeep Das De, Sanjeet Singh Avtaar Singh, Alan Kirk
    Aim: Immunosuppression has evolved since the first successful orthotopic heart transplant 50 years ago. Currently, calcineurin inhibitors lie at the focal point of the immunosuppressive regimen. However, these drugs exhibit a variety of side effects, including hyperglycaemia. This in turn compounds the risk of cardiovascular disease. There is conflict around which calcineurin inhibitor, tacrolimus or ciclosporin, is more likely to induce diabetes. Methods: A retrospective analysis of data from 52 patients who had received a heart transplantation at the Scottish heart transplant unit between... Read more
    This article belongs to the Special Issue State of the Art in Cardiovascular Surgery
    Vessel Plus 2018;2:24. | doi:10.20517/2574-1209.2018.27
    Published on: 13 Sep 2018  | Viewed:266  | Downloaded:37
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  • Review|Open Access

    Recent advances in cerebral cavernous malformation research

    Akhil Padarti, Jun Zhang
    Cerebral cavernous malformations (CCM) are manifested by microvascular lesions characterized by leaky endothelial cells with minimal intervening parenchyma predominantly in the central nervous system predisposed to hemorrhagic stroke, resulting in focal neurological defects. Till date, three proteins are implicated in this condition: CCM1 (KRIT1), CCM2 (MGC4607), and CCM3 (PDCD10). These multi-domain proteins form a protein complex via CCM2 that function as a docking site for the CCM signaling complex, which modulates many signaling pathways. Defects in the formation of this signaling... Read more
    This article belongs to the Special Issue Cerebrovascular Diseases
    Vessel Plus 2018;2:21. | doi:10.20517/2574-1209.2018.34
    Published on: 28 Aug 2018  | Viewed:437  | Downloaded:22
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  • Review|Open Access

    Advantages and disadvantages of total arterial coronary artery bypass graft as compared to venous coronary artery bypass graft

    Dickson Dewantoro, Antonio Nenna, Umberto Satriano, Massimo Chello, Cristiano Spadaccio
    Considering the plethora of literature about surgical revascularization, this editorial aims to discuss the most recent studies about the effects of total arterial coronary artery bypass graft (TACABG) compared with CABG that involves venous graft (VCABG) in patients with multivessel coronary artery disease. Patients were sampled from published papers that studied various aspects involving TACABG or VCABG. Resulting samples were used to compare the complexity and 5 years’ outcomes of TACABG to VCABG in the revascularization of coronary arteries. TACABG provides a better prognosis with... Read more
    This article belongs to the Special Issue State of the Art in Cardiovascular Surgery
    Vessel Plus 2018;2:20. | doi:10.20517/2574-1209.2018.50
    Published on: 16 Aug 2018  | Viewed:566  | Downloaded:34
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  • Original Article|Open Access

    Genetic variants of renin on the prevalence of diabetic nephropathy

    Pulakes Purkait, Kalpataru Halder, Jammigumpula Masthanaiah Naidu, Biswanath Sarkar
    Aim: Renin, a component of the Renin-Angiotensin-Aldosterone System (RAAS), is produced in the juxtaglomerular cells of the kidney. It is an important factor for the regulation of blood pressure and electrolyte balance and encoded by the REN gene. Recent studies suggest that the RAAS is a regulator of kidney functions. Individuals with REN variants have been associated with high blood pressure. We substantiated the hypothesis that genetic variants of REN gene have significant association with prevalence of nephropathy and in the development of nephropathy in type 2 diabetes mellitus (T2DM).... Read more
    Vessel Plus 2018;2:19. | doi:10.20517/2574-1209.2018.16
    Published on: 14 Aug 2018  | Viewed:445  | Downloaded:19
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  • Case Report|Open Access

    Iatragenic injury to axillary artery: rescued by endovascular repair

    Chih-Chen Kao, Yao-Kuang Huang
    Most of axillo-subclavian artery injuries are due to violence. Iatrogenic injuries to such vessels are relatively rare. We hereby present the first report of pigtail catheter insertion for right upper chest wall hematoma drainage resulting in penetration of axillary artery and pseudoaneurysm formation. A 39-year-old male victim of motor vehicle accident developed right upper chest wall hematoma after initial conservative treatment. Subsequent admission was arranged and pigtail catheter drainage was performed under sonography guidance. The procedure caused penetrating injury to his right... Read more
    Vessel Plus 2018;2:18. | doi:10.20517/2574-1209.2018.42
    Published on: 10 Aug 2018  | Viewed:281  | Downloaded:10
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  • Review|Open Access

    Who is the next for aortic valve implantation? Present and future indications

    Giuseppe Verolino, Alessia Delli Veneri, Myriam Carpenito, Francesco Piccirillo, Leonardo Aurino, Annunziata Nusca
    Aortic valve stenosis (AS) represents the most prevalent valvular defect worldwide. It is a progressive disease with a long latency interval and a poor prognosis after symptoms present. According to current European Society of Cardiology guidelines, transcatheter aortic valve implantation (TAVI) is recommended in all patients with severe symptomatic AS and a predicted survival longer than one year, who are not suitable for surgical valve replacement. Despite these recommendations, several studies over the past few years suggest extending these indications towards lower risk AS populations.... Read more
    This article belongs to the Special Issue State of the Art in Cardiovascular Surgery
    Vessel Plus 2018;2:17. | doi:10.20517/2574-1209.2018.32
    Published on: 2 Aug 2018  | Viewed:479  | Downloaded:24
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  • Original Article|Open Access

    Immunohistochemistry of the circadian clock in mouse and human vascular tissues

    Ciprian B. Anea, Ana M. Merloiu, David J. R. Fulton, Vijay Patel, R. Dan Rudic
    Aim: The circadian clock is a molecular network that controls the body physiological rhythms. In blood vessels, the circadian clock components modulate vascular remodeling, blood pressure, and signaling. The goal in this study was to determine the pattern of expression of circadian clock proteins in the endothelium, smooth muscle, and adventitia of the vasculature of human and mouse tissues. Methods: Immunohistochemistry was performed in frozen sections of mouse aorta, common carotid artery, femoral artery, lung, and heart at 12 AM and 12 PM for Bmal1, Clock, Npas2, Per and other clock... Read more
    This article belongs to the Special Issue Vascular Remodeling 2018: the Updates
    Vessel Plus 2018;2:16. | doi:10.20517/2574-1209.2018.46
    Published on: 20 Jul 2018  | Viewed:607  | Downloaded:44
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  • Review|Open Access

    Histone deacetylases in vascular permeability and remodeling associated with acute lung injury

    Laszlo Kovacs, Anita Kovacs-Kasa, Alexander D. Verin, David Fulton, Rudolf Lucas, Yunchao Su
    Acute lung injury (ALI) is a severe progressive disorder that arises from a wide range of causes such as toxins or inflammation, resulting in significant morbidity and mortality. There are no effective therapeutic options apart from mechanical ventilation strategies. While the mechanisms that govern the clinically relevant process of increased endothelial cell (EC) permeability and remodeling associated with ALI are under intense investigation, our knowledge of the processes that determine barrier enhancement or preservation are far from completion. Recently, epigenetic mechanisms have... Read more
    This article belongs to the Special Issue Vascular Remodeling 2018: the Updates
    Vessel Plus 2018;2:15. | doi:10.20517/2574-1209.2018.06
    Published on: 10 Jul 2018  | Viewed:409  | Downloaded:20
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  • Review|Open Access

    Percutaneous coronary intervention in the elderly: current updates and trends

    Mohammed J. Arisha, Dina A. Ibrahim, Ahmed A. Abouarab, Mohamed Rahouma, Mohamed K. Kamel, Massimo Baudo, Kritika Mehta, Mario F. L. Gaudino
    Ischemic heart disease is the leading cause of death with acute coronary syndrome accounting for more than 30% of causes of mortality in the elderly population. The rate of growth of the older segment of the population has increased exponentially and will become more pronounced in the future. Historically, there has been a paucity of clinical trials investigating the challenges and outcomes of more invasive treatment strategies such as percutaneous coronary intervention (PCI) for that very segment of the population. However, the safety, efficacy, and outcomes of PCI in the older population... Read more
    Vessel Plus 2018;2:14. | doi:10.20517/2574-1209.2018.29
    Published on: 9 Jul 2018  | Viewed:1089  | Downloaded:73
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  • Review|Open Access

    Research into biodegradable polymeric stents: a review of experimental and modelling work

    Tianyang Qiu, Liguo Zhao
    Bioresorbable stents (BRSs) are regarded as the next-generation medical devices to treat blocked or diseased arteries. The use of BRSs aims to reduce the risk of late stent thrombosis and long-term tissue inflammation associated with permanent metallic stents. BRSs are designed to relieve symptoms immediately and also provide mechanical support for an appropriate time period before they are fully absorbed by human body. To promote clinical adoption of BRSs or even to substitute metallic stents, the mechanical performance of BRSs needs to be thoroughly investigated and quantitatively... Read more
    Vessel Plus 2018;2:12. | doi:10.20517/2574-1209.2018.13
    Published on: 5 Jun 2018  | Viewed:1062  | Downloaded:59
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