• Review|Open Access

    Research into biodegradable polymeric stents: a review of experimental and modelling work

    Tianyang Qiu , Liguo Zhao
    Bioresorbable stents (BRSs) are regarded as the next-generation medical devices to treat blocked or diseased arteries. The use of BRSs aims to reduce the risk of late stent thrombosis and long-term tissue inflammation associated with permanent metallic stents. BRSs are designed to relieve symptoms immediately and also provide mechanical support for an appropriate time period before they are fully absorbed by human body. To promote clinical adoption of BRSs or even to substitute metallic stents, the mechanical performance of BRSs needs to be thoroughly investigated and quantitatively... Read more
    Vessel Plus 2018;2:12. | doi:10.20517/2574-1209.2018.13
    Published on: 5 Jun 2018  | Viewed:189  | Downloaded:16
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  • Original Article|Open Access

    Plasmatic biomarkers of inflammation correlate with 18FDG-PET-CT and microembolic signals in patients with carotid stenosis

    Hubertus Mueller , Loraine Fisch , Christophe Bonvin , Karl Lovblad , Osman Ratib , Patrice Lalive , Stephane Pagano , Nicolas Vuilleumier , Jean-Pierre Willi , Roman Sztajzel
    Aim: To determine whether plasmatic biomarkers correlate with 18fluoro-2-deoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET-CT) and presence of microembolic signals (MES) detected by transcranial Doppler in patients with carotid stenosis. Methods: 18FDG-PET-CT and MES detection was performed in consecutive patients with 50% to 99% symptomatic or asymptomatic carotid stenosis. Uptake index was defined by a target to background ratio (TBR) between maximum standardized uptake value of the carotid plaque and the average uptake of the jugular veins. The analysis of... Read more
    This article belongs to the Special Issue Cerebrovascular Diseases
    Vessel Plus 2018;2:13. | doi:10.20517/2574-1209.2018.19
    Published on: 5 Jun 2018  | Viewed:46  | Downloaded:3
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  • Case Report|Open Access

    Bortezomib-induced posterior reversible encephalopathy syndrome: a case report

    Paolo Candelaresi , Maria Chiara Casorio
    Posterior reversible encephalopathy syndrome (PRES) is an uncommon neurological syndrome due to autoregulation breakthrough with subsequent predominantly vasogenic oedemain associated with several clinical conditions. It is being increasingly reported in antineoplastic-treated patients. Here we report the case of a 72-year-old man who developed PRES during the second cycle of bortezomib treatment for multiple myeloma. Unlike usual PRES cases, only moderate hypertension was present at symptom onset, supporting the hypothesis that alterations of the vascular endothelium and... Read more
    This article belongs to the Special Issue Cerebrovascular Diseases
    Vessel Plus 2018;2:11. | doi:10.20517/2574-1209.2018.09
    Published on: 18 May 2018  | Viewed:106  | Downloaded:8
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  • Case Report|Open Access

    The first INSPIRIS RESILIA Aortic ValveTM replacement (Edwards Lifesciences) in endocarditis

    Sanjeet Singh Avtaar Singh , Gwyn Beattie , David Reid , Philip Curry
    There is an increasing number of patients who have surgery during the active phase of infective endocarditis. Despite the decreasing in-hospital mortality and increasing early intervention rate, optimal timing for surgery remains a difficult decision. For patients with mental illnesses, the choice of valve is another factor to consider as non-adherence may lead to serious adverse events Antipsychotic medications may also alter the metabolism of vitamin K antagonists increasing the risk of stroke or major haemorrhage. We report a case of a 19-year-old man with a history of Ehlers-Danlos... Read more
    This article belongs to the Special Issue State of the Art in Cardiovascular Surgery
    Vessel Plus 2018;2:10. | doi:10.20517/2574-1209.2018.18
    Published on: 15 May 2018  | Viewed:343  | Downloaded:8
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  • Case Report|Open Access

    Repair of mitral subvalvular apparatus and a calcified left ventricle aneurysm

    Kasra Shaikhrezai , Sanjeet Singh Avtaar Singh , Karim Morcos , Steve Hunter
    Left ventricle (LV) myocardial infarction may result in changes to the structure of the subvalvular apparatus. This may lead to a functional regurgitation if accompanied by annular dilatation preventing coaptation of leaflets. Scar tissue formation in the left ventricle may also lead to aneurysm of the left ventricle. This can then calcify, making repair of the leaflet technically challenging. We present a case of a mitral valve repair with concomitant repair of left ventricle aneurysm in a 75-year-old gentleman who suffered an ST-segment elevation myocardial infarction to the lateral wall... Read more
    This article belongs to the Special Issue State of the Art in Cardiovascular Surgery
    Vessel Plus 2018;2:9. | doi:10.20517/2574-1209.2018.17
    Published on: 10 May 2018  | Viewed:405  | Downloaded:9
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  • Review|Open Access

    Ruptured isolated descending thoracic aortic aneurysm: open or endovascular repair?

    Amer Harky , Nichola Manu , Rafal Al Nasiri , Dilan Sanli , Ciaran Grafton-Clarke , Jeffrey Shi Kai Chan , Chris Ho Ming Wong
    Descending thoracic aortic aneurysm management has gained momentum and became a topic of many debates at international levels since the evolution of endovascular repair. Ruptured descending thoracic aortic aneurysm is a clinical emergency which is associated with high mortality and morbidity rates if not managed properly. Prior to thoracic endovascular aortic repair (TEVAR), open repair (OR) was the gold standard management, however since the evolution of TEVAR, this has changed. Several centers have reported many of their experiences and published that TEVAR can provide equal or even... Read more
    This article belongs to the Special Issue Ruptured Aneurysms: Open and Endovascular Repair
    Vessel Plus 2018;2:8. | doi:10.20517/2574-1209.2018.12
    Published on: 7 May 2018  | Viewed:317  | Downloaded:14
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  • Case Report|Open Access

    Endovascular treatment of an iatrogenic superior mesenteric arteriovenous fistula after Nissen fundoplication

    S. Keisin Wang , Jie Xie , Raghu L. Motaganahalli
    We present a case of a superior mesenteric arteriovenous fistula (SMAVF) diagnosed four years after index Nissen fundoplication and examine the associated imaging, clinical course, and surgical treatment followed by a review of the limited, available literature. From a transbrachial approach, a covered stent was successfully deployed in the superior mesenteric artery to exclude the fistula after confirmation of the site of pathology on both digital subtraction angiography and intravascular ultrasound. Follow-up imaging demonstrated continued exclusion of the anomalous fistula with complete... Read more
    Vessel Plus 2018;2:7. | doi:10.20517/2574-1209.2018.15
    Published on: 27 Apr 2018  | Viewed:330  | Downloaded:10
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  • Original Article|Open Access

    Adherence to guidelines: primary prevention with aspirin in 1125 medical check-up participants

    Jin Hee Im , Sang Won Han , Seon Yeong Lee , Jong Sam Baik
    Aim: The aim of the present study was to assess the 10-year cardiovascular disease (CVD) risk and to apply the current recommendations on aspirin use for primary prevention in Korean participants undergoing a medical check-up. Methods: Adults aged 50 to 69 years were eligible for the study if they did not have a history of atherosclerotic CVD (ASCVD) or stroke. The 10-year CVD risk was calculated using the ASCVD risk estimator ( Results: A total of 1125 participants were enrolled in this study. The mean age was 57 years, and 32% of the participants... Read more
    This article belongs to the Special Issue Cerebrovascular Diseases
    Vessel Plus 2018;2:5. | doi:10.20517/2574-1209.2018.07
    Published on: 18 Apr 2018  | Viewed:420  | Downloaded:19
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  • Review|Open Access

    Metabolic risk in depression and treatment with selective serotonin reuptake inhibitors: are the metabolic syndrome and an increase in cardiovascular risk unavoidable?

    Mervin Chávez-Castillo , Ángel Ortega , Manuel Nava , Jorge Fuenmayor , Victor Lameda , Manuel Velasco , Valmore Bermúdez , Joselyn Rojas-Quintero
    Depression is one of the most common psychiatric disorders, and has become an epidemic in modern medical practice; notorious for frequently co-occurring with multiple comorbidities, especially cardiovascular disease (CVD), type 2 diabetes mellitus (DM2), and its various risk factors comprised in the metabolic syndrome (MS). Selective serotonin reuptake inhibitors (SSRIs) are the most widely used class of psychotropic drugs in this and many other clinical scenarios; yet their impact on cardiometabolic health has not been elucidated. The objective of this review was to summarize current views... Read more
    Vessel Plus 2018;2:6. | doi:10.20517/2574-1209.2018.02
    Published on: 18 Apr 2018  | Viewed:1013  | Downloaded:80
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  • Editorial|Open Access

    Early treatment of functional tricuspid regurgitation at the time of mitral valve surgery: an increased risk or an additional benefit?

    Paolo Nardi , Calogera Pisano , Antonio Pellegrino , Fabio Bertoldo , Sabrina Ferrante , Monica Greci , Sara Rita Vacirca , Marco Russo , Giovanni Ruvolo
    Vessel Plus 2018;2:4. | doi:10.20517/2574-1209.2017.35
    Published on: 13 Mar 2018  | Viewed:706  | Downloaded:53
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  • Case Report|Open Access

    Temporizing amplatzer closure of an aorto-enteric fistula associated with a blind aortic stump via a translumbar approach

    S. Keisin Wang , Justin R. King , Ashley R. Gutwein , Raghu L. Motaganahalli , Andres Fajardo , Gary W. Lemmon
    We present a case of an aorto-enteric fistula (AEF) with chronic, persistent bleeding from a blind aortic stump managed by endovascular means. This novel approach may have extended the life of a patient who would otherwise have been subject to a high perioperative morbidity or persistent bleeding and death. While our patient ultimately expired, we believe this technique can be considered for temporization in highly-selected patients. Read more
    Vessel Plus 2018;2:3. | doi:10.20517/2574-1209.2017.38
    Published on: 7 Feb 2018  | Viewed:1111  | Downloaded:67
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  • Review|Open Access

    Surgical revascularization for acute coronary syndromes: a narrative review

    Joseph H. Joo , Joshua M. Liao , Faisal G. Bakaeen , Danny Chu
    Acute coronary syndrome (ACS) comprises a spectrum of disease that includes unstable angina, non-ST-elevation myocardial infarction, and ST-elevation myocardial infarction. Clinical management of patients with ACS has greatly evolved over the last two decades, but ACS remains an important cause of morbidity and mortality in patients with coronary artery disease. This narrative review describes the indication, timing, and approaches to surgical revascularization in the context of ACS. In particular, the review discusses and compares the utilization of off-pump coronary artery bypass grafting... Read more
    Vessel Plus 2018;2:2. | doi:10.20517/2574-1209.2017.36
    Published on: 2 Feb 2018  | Viewed:819  | Downloaded:110
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  • Review|Open Access

    Traumatic pulmonary artery injury: a review of the recent literature

    Youichi Yanagawa , Kouhei Ishikawa , Hiroki Nagasawa , Ikuto Takeuchi , Kei Jitsuiki , Hiromichi Ohsaka , Kazuhiko Omori
    Pulmonary artery injury (PAI) is rare, lethal clinical entity. Traumatic PAI is anatomically classified into transection/rupture/laceration, pseudoaneurysm, dissection and fistula. In addition, traumatic PAI is clinically classified into two major categories: iatrogenic and non-iatrogenic, depending on the mechanism of the trauma. The frequency, clinical symptoms and treatment differ between the two clinical categories. If PAI can be managed appropriately and promptly in patients without cardiac arrest, the patient may be saved, as PAI can be easily controlled with appropriate procedures... Read more
    Vessel Plus 2018;2:1. | doi:10.20517/2574-1209.2017.37
    Published on: 26 Jan 2018  | Viewed:979  | Downloaded:81
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    Relationship between peculiarities of atrial fibrillation, body mass index and adipokines levels

    Oleksandr Bilovol , Yuliya Shaposhnikova , Iryna Ilchenko , Anna Shalimova
    Aim: To assess the value of body mass index (BMI) and adipokine levels in predicting development of atrial fibrillation (AF) in the general population. Methods: Three hundred and ninety eight patients were examined for the presence of phenotype metabolically healthy obesity (MHO), according to the Wildman criteria; adipokine levels were assessed by enzyme immunoassay method; AF was assessed by electrocardiography (ECG) and/or by ECG diurnal monitoring. Results: Obesity (group 1) and overweight (group 2) was present in 23.7% and 42.0% of participants; while 21.1% were normal body weight... Read more
    Vessel Plus 2017;1:196-201. | doi:10.20517/2574-1209.2017.17
    Published on: 28 Dec 2017  | Viewed:1590  | Downloaded:66
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    Proinflammatory monocyte polarization in type 2 diabetes mellitus and coronary heart disease

    Nikita G. Nikiforov , Karina O. Galstyan , Liudmila V. Nedosugova , Natalia V. Elizova , Kira I. Kolmychkova , Ekaterina A. Ivanova
    Aim: Type 2 diabetes mellitus (T2DM) is associated with rapid progression of atherosclerosis. There is no doubt that inflammation is involved in atherogenesis. Recent studies showed the relationship between the development of atherosclerotic plaque formation and the amount of pro-inflammatory (M1) activated macrophages in situ. Methods: The authors studied the ability of circulating monocytes isolated from patients with diabetes (n = 28), coronary heart disease (CHD) (n = 27) and healthy subjects (n = 50) to be activated into M1 phenotype in vitro. Results: Increased levels of basal and... Read more
    Vessel Plus 2017;1:192-5. | doi:10.20517/2574-1209.2017.21
    Published on: 28 Dec 2017  | Viewed:892  | Downloaded:77
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    New markers of atherosclerosis: a threshold level of heteroplasmy in mtDNA mutations

    Margarita A. Sazonova , Anastasia I. Ryzhkova , Vasily V. Sinyov , Elena V. Galitsyna , Varvara A. Orekhova , Alexandra A. Melnichenko , Alexander N. Orekhov , Alessio L. Ravani , Igor A. Sobenin
    Aim: The aim of the present article was the detection of threshold heteroplasmy level of mitochondrial DNA mutations, above which a patient is at increased risk of atherosclerotic lesions. Besides, this parameter was detected for mutations, in which after reaching threshold heteroplasmy level, a protective antiatherogenic effect started to appear. Methods: The participants of the study were 700 women and men from the Moscow region. Fragments of DNA, amplified by polymerase chain reaction, were analyzed with pyrosequencing technology. Then on the basis of pyrograms’ peaks in the samples, the... Read more
    Vessel Plus 2017;1:182-91. | doi:10.20517/2574-1209.2017.16
    Published on: 28 Dec 2017  | Viewed:1390  | Downloaded:83
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    Is insulin pro-atherogenic at the cellular level?

    Igor A. Sobenin , Varvara A. Orekhova , Andrey V. Grechko , Alexander N. Orekhov
    Aim: This study was undertaken to test the hypothesis that insulin treatment has unexpected pro-atherogenic effects at the cellular level, namely, proliferative activity and intracellular cholesterol content. Methods: Primary cultures of subendothelial cells derived from non-atherosclerotic human aorta and mouse peritoneal macrophages were used to investigate the in vitro effect of insulin on atherosclerosis-related parameters, such as cellular cholesterol content and proliferation rate. Additionally, the effect of insulin treatment in 33 type 1 diabetic patients on serum atherogenicity... Read more
    Vessel Plus 2017;1:174-81. | doi:10.20517/2574-1209.2017.19
    Published on: 28 Dec 2017  | Viewed:882  | Downloaded:64
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  • Review|Open Access

    Energetic metabolism in cardiomyocytes: molecular basis of heart ischemia and arrhythmogenesis

    María Sofía Martínez , Andrés García , Eliana Luzardo , Mervin Chávez-Castillo , Luis Carlos Olivar , Juan Salazar , Manuel Velasco , Joselyn Joanna Rojas Quintero , Valmore Bermúdez
    Cardiac muscle contraction is a strictly regulated process which conjugates a series of electrophysiological, biochemical and mechanic events, resulting in the pumping of blood to all bodily tissues. These phenomena require a very high energetic demand both for generating the necessary mechanical force, and for maintaining cellular homeostasis during the process. In the myocardium, fatty acids (FA) represent the main energy substrate, although other secondary substrates, such as glucose and ketone bodies, may also be used. Nevertheless, under certain conditions such as heart failure or... Read more
    Vessel Plus 2017;1:230-41. | doi:10.20517/2574-1209.2017.34
    Published on: 28 Dec 2017  | Viewed:2011  | Downloaded:133
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  • Topic: Atherosclerosis and Related Diseases|Open Access

    HDL subfraction distribution and HDL function in untreated dyslipidemic patients

    Mariann Harangi , Anita Szentpéteri , Bíborka Nádró , Hajnalka Lőrincz , Ildikó Seres , Dénes Páll , György Paragh
    Aim: The protective role of high-density lipoprotein (HDL) against atherosclerosis is well known. However, both structural and functional changes of the HDL particles may affect its protective efficacy. Increased levels of HDL-associated myeloperoxidase (MPO) and decreased HDL-linked paraoxonase-1 (PON1) activity have been reported in dyslipidemic patients. Some changes in HDL subfraction distributions were also studied previously, but data on structural and functional changes in dyslipidemia are not complete. Therefore, the authors aimed to evaluate these qualitative and quantitative... Read more
    Vessel Plus 2017;1:166-73. | doi:10.20517/2574-1209.2017.27
    Published on: 28 Dec 2017  | Viewed:944  | Downloaded:65
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  • Review|Open Access

    An overview of different methods of myocardial protection currently employed peri-transplantation

    Sanjeet Singh Avtaar Singh , Sudeep Das De , Cristiano Spadaccio , Colin Berry , Nawwar Al-Attar
    Myocardial protection is integral to the functioning of hearts in day to day cardiac surgery. However, due to the longer ischaemic times, it becomes pivotal in the management of organs during transplantation. There are many different strategies employed to ensure diligent and judicious myocardial protection during donor management, transportation of the heart and the post-operative period. Given the limited supply of organs and the increasing waiting lists for heart transplants worldwide, it has become an area of renewed interest with many innovations and inventions using the principles of... Read more
    Vessel Plus 2017;1:213-29. | doi:10.20517/2574-1209.2017.26
    Published on: 28 Dec 2017  | Viewed:1099  | Downloaded:62
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