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  • image 18 Jan 2018 Review| Open Access

    A primer on recent developments in cancer immunotherapy, with a focus on neoantigen vaccines

    Taku A. Tokuyasu , Jian-Dong Huang

    ancer immunotherapy has now been conclusively shown to be capable of producing durable responses for a substantial number of patients. Adoptive cell transfer and checkpoint blockade therapies in particular both demonstrate that antigen-specific immune responses can be dramatically effective, even...

    Journal of Cancer Metastasis and Treatment [HTML] [PDF] Viewed:76 Downloaded:0
  • image 28 Dec 2017 Topic: Achalasia Management: the South American viewpoint| Open Access

    Heller-Pinotti, a modified partial fundoplication associated with myotomy to treat achalasia: technical and final results from 445 patients

    Edno Tales Bianchi , Rubens Antonio Aissar Sallum , Sergio Szachnowicz , Francisco Carlos Bernal Costa Seguro , Andre Fonseca Duarte , Julio Rafael Mariano da Rocha , Ivan Cecconello

    Aim: The need for an antireflux procedure after myotomy is no longer as controversial as it used to be. However, the choice of the best fundoplication after myotomy is still controversial. The authors present the results of laparoscopic myotomies associated with postero-latero-anterior...

    Mini-invasive Surgery [HTML] [PDF] Viewed:399 Downloaded:17
  • image 28 Dec 2017 Review| Open Access

    Energetic metabolism in cardiomyocytes: molecular basis of heart ischemia and arrhythmogenesis

    María Sofía Martínez , Andrés García , Eliana Luzardo , Mervin Chávez-Castillo , Luis Carlos Olivar , Juan Salazar , Manuel Velasco , Joselyn Joanna Rojas Quintero , Valmore Bermúdez

    Cardiac muscle contraction is a strictly regulated process which conjugates a series of electrophysiological, biochemical and mechanic events, resulting in the pumping of blood to all bodily tissues. These phenomena require a very high energetic demand both for generating the necessary mechanical...

    Vessel Plus [HTML] [PDF] Viewed:398 Downloaded:24
  • image 25 Dec 2017 Original Article| Open Access

    Shear bond strength of universal adhesive systems to a bioactive dentin substitute (Biodentine®) at different time intervals

    Sedef Aksoy , Murat Ünal

    Aim: The aim of this study was to compare the shear bond strength (SBS) of various adhesive systems to a bioactive dentin substitute Biodentine® with different time intervals. Methods: Three hundred and fifty cylindrical acrylic blocks with a hole (4 mm diameter and 2 mm height) were prepared....

    Stomatological Disease and Science [HTML] [PDF] Viewed:837 Downloaded:36
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  • image 34869 Topic: Infectious Disease of Central Nervous System| Open Access

    Current diagnosis and treatment of cryptococcal meningitis without acquired immunodeficiency syndrome

    Xiao-Su Guo , Hui Bu , Jun-Ying He , Yue-Li Zou , Yue Zhao , Yuan-Yuan Li , Jun-Zhao Cui , Ming-Ming Zheng , Wei-Xin Han , Ze-Yan Zhao

    Cryptococcal meningitis (CM) is a central nervous system infectious disease caused by Cryptococcus. It is the most common fungal infection in the central nervous system, accounting for about 48% of fungal infection. The disease occurs mainly in acquired immunodeficiency syndrome (AIDS) patients...

    Neuroimmunology and Neuroinflammation [HTML] [PDF] Viewed:34869 Downloaded:286
  • image 219517 Review| Open Access

    Long non-coding RNAs as key regulators of cancer metastasis

    Pratirodh Koirala , De-Hong Zou , Yin-Yuan Mo

    The recent advances in functional genomics have discovered that a large number of long non-coding RNAs (lncRNAs) are pervasively transcribed from the human genome. Increasing evidence further indicates that lncRNAs are important for gene expression during cell differentiation and development...

    Journal of Cancer Metastasis and Treatment [HTML] [PDF] Viewed:219517 Downloaded:686
  • image 21517 Topic: Biomaterials for Plastic and Aesthetic Surgery| Open Access

    Intradermal fillers for minimally invasive treatment of facial aging

    Zhi Yuan (William) Lin , Vishva Shah , Arvind Dhinakar , Lara Yildirimer , Wen-Guo Cui , Xin Zhao

    The ever-increasing interest in retaining a youthful physical appearance has facilitated the development of various minimally invasive dermatological techniques. The use of intradermal fillers can be incorporated into dermatological practices with minimal overhead costs. This strategy addresses...

    Plastic and Aesthetic Research [HTML] [PDF] Viewed:21517 Downloaded:1010
  • image 29320 Review| Open Access

    Hepatitis B virus molecular biology and pathogenesis

    R. Jason Lamontagne , Sumedha Bagga , Michael J. Bouchard

    As obligate intracellular parasites, viruses need a host cell to provide a milieu favorable to viral replication. Consequently, viruses often adopt mechanisms to subvert host cellular signaling processes. While beneficial for the viral replication cycle, virus-induced deregulation of host...

    Hepatoma Research [HTML] [PDF] Viewed:29320 Downloaded:924
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